SASH1

SASH1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2EBP
Identifiers
Aliases	SASH1, SH3D6A, dJ323M4, dJ323M4.1, SAM and SH3 domain containing 1, DUH1, CAPOK
External IDs	OMIM: 607955 MGI: 1917347 HomoloGene: 69182 GeneCards: SASH1
Gene location (Human) Chr. Chromosome 6 (human) Band 6q24.3-q25.1 Start 148,272,304 bp End 148,552,044 bp
Gene location (Mouse) Chr. Chromosome 10 (mouse) Band 10|10 A1 Start 8,597,983 bp End 8,761,814 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in synovial joint external globus pallidus subthalamic nucleus inferior ganglion of vagus nerve oral cavity Achilles tendon superior vestibular nucleus corpus callosum ventral tegmental area tibia Top expressed in medial geniculate nucleus lateral geniculate nucleus substantia nigra suprachiasmatic nucleus ventral tegmental area medial dorsal nucleus lateral hypothalamus body of femur mammillary body calvaria More reference expression data BioGPS More reference expression data
Gene ontology Molecular function mitogen-activated protein kinase kinase kinase binding molecular adaptor activity protein C-terminus binding protein kinase binding Cellular component protein-containing complex Biological process positive regulation of endothelial cell migration positive regulation of lipopolysaccharide-mediated signaling pathway positive regulation of JUN kinase activity regulation of protein K63-linked ubiquitination positive regulation of p38MAPK cascade regulation of protein autoubiquitination protein polyubiquitination positive regulation of NIK/NF-kappaB signaling positive regulation of angiogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23328 70097 Ensembl ENSG00000111961 ENSMUSG00000015305 UniProt O94885 P59808 RefSeq (mRNA) NM_015278 NM_001346505 NM_001346506 NM_001346507 NM_001346508 NM_001346509 NM_175155 RefSeq (protein) NP_001333434 NP_001333435 NP_001333436 NP_001333437 NP_001333438 NP_056093 NP_780364 Location (UCSC) Chr 6: 148.27 – 148.55 Mb Chr 10: 8.6 – 8.76 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

SAM and SH3 domain-containing protein 1 is a protein that in humans is encoded by the SASH1 gene.

Further reading

• Rimkus C, Martini M, Friederichs J, et al. (2007). "Prognostic significance of downregulated expression of the candidate tumour suppressor gene SASH1 in colon cancer". Br. J. Cancer. 95 (10): 1419–23. doi:10.1038/sj.bjc.6603452. PMC 2360597. PMID 17088907.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Cheng J, Kapranov P, Drenkow J, et al. (2005). "Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution". Science. 308 (5725): 1149–54. Bibcode:2005Sci...308.1149C. doi:10.1126/science.1108625. PMID 15790807. S2CID 13047538.
• Benzinger A, Muster N, Koch HB, et al. (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell. Proteomics. 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.