S100A3

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S100A3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesS100A3, S100E, S100 calcium binding protein A3
External IDsOMIM: 176992 MGI: 1338849 HomoloGene: 2223 GeneCards: S100A3
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002960

NM_011310
NM_001355597
NM_001355600
NM_001355602

RefSeq (protein)

NP_002951

NP_035440
NP_001342526
NP_001342529
NP_001342531

Location (UCSC)Chr 1: 153.55 – 153.55 MbChr 3: 90.49 – 90.51 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

S100 calcium-binding protein A3 (S100A3) is a protein that in humans is encoded by the S100A3 gene.[5][6]

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein has the highest content of cysteines of all S100 proteins, has a high affinity for Zinc, and is highly expressed in human hair cuticle. The precise function of this protein is unknown.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000188015 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000001021 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Engelkamp D, Schafer BW, Mattei MG, Erne P, Heizmann CW (Aug 1993). "Six S100 genes are clustered on human chromosome 1q21: identification of two genes coding for the two previously unreported calcium-binding proteins S100D and S100E". Proc Natl Acad Sci U S A. 90 (14): 6547–51. Bibcode:1993PNAS...90.6547E. doi:10.1073/pnas.90.14.6547. PMC 46969. PMID 8341667.
  6. ^ a b "Entrez Gene: S100A3 S100 calcium binding protein A3".

Further reading