Reticulate acropigmentation of Kitamura

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Reticulate acropigmentation of Kitamura
Other names: RAK[1]
PMC4037953 IJD-59-290-g001.png
Reticulate hyperpigmentation on: a) Dorsa of both hands b) Dorsa of both feet c) Neck d) Axilla
SpecialtyDermatology
SymptomsColored freckle-like and slightly depressed spots arranged in a lace-like pattern on the backs of hands and feet[2]
Usual onsetAdolescence and young adults[2]
CausesAutosomal-dominant[2]
Differential diagnosisDowling–Degos disease[2]
FrequencyRare[2]

Reticulate acropigmentation of Kitamura is a type of pigmentation disorder of the skin.[2] It presents with colored freckle-like and slightly depressed spots arranged in a lace-like pattern on the backs of hands and feet.[2] It tends to occur in skin folds of adolescents and early adulthood, and darkens over time.[2]

It is inherited in an autosomal-dominant fashion.[2]

The condition is rare.[2] It was first described in Japan, before recognising that is also occurs elsewhere.[2]


Genetics

This condition is associated with mutations in the a disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) gene. This association was first shown in 2013.

See also

References

  1. "Orphanet: Reticulate acropigmentation of Kitamura". www.orpha.net. Archived from the original on 25 November 2020. Retrieved 23 April 2019.
  2. 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 James, William D.; Elston, Dirk; Treat, James R.; Rosenbach, Misha A.; Neuhaus, Isaac (2020). "36. Disturbances of pigmentation: Reticulate acropigmentation of Kitamura". Andrews' Diseases of the Skin: Clinical Dermatology (13th ed.). Edinburgh: Elsevier. p. 867. ISBN 978-0-323-54753-6. Archived from the original on 2022-08-13. Retrieved 2022-08-12.

External links

Classification
External resources