Reticulate acropigmentation of Kitamura

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Reticulate acropigmentation of Kitamura
Other names: RAK[1]
PMC4037953 IJD-59-290-g001.png
Reticulate hyperpigmentation on: a) Dorsa of both hands b) Dorsa of both feet c) Neck d) Axilla

Reticulate acropigmentation of Kitamura consists of linear palmar pits and pigmented macules 1 to 4 mm in diameter on the volar and dorsal aspects of the hands and feet, usually inherited in an autosomal-dominant fashion.[2]: 856 [3][4]


This condition is associated with mutations in the a disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) gene. This association was first shown in 2013.

See also


  1. RESERVED, INSERM US14-- ALL RIGHTS. "Orphanet: Reticulate acropigmentation of Kitamura". Archived from the original on 25 November 2020. Retrieved 23 April 2019.
  2. James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. ISBN 0-7216-2921-0.
  3. Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 978-1-4160-2999-1.
  4. Vasudevan B, Verma R, Badwal S, Pragasam V, Moorchung N, Badad A (2014). "A case of reticulate acropigmentation of kitamura: dowling degos disease overlap with unusual clinical manifestations". Indian J Dermatol. 59 (3): 290–2. doi:10.4103/0019-5154.131408. PMC 4037953. PMID 24891663.

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