|Other names: Reticular pigmented anomaly of the flexures|
|Symptoms||Lace-like darkening in skin folds|
|Usual onset||After puberty|
|Diagnostic method||Visualisation, skin biopsy|
|Differential diagnosis||Reticulate acropigmentation of Kitamura, Haber syndrome, neurofibromatosis type 1, acanthosis nigricans|
|Frequency||Rare, <50 cases worldwide (as of 2022)|
Dowling–Degos disease (DDD), is a type of reticulate pigmentary disorder of the skin. It presents with small dark spots and bumps that form a lace-like pattern in skin folds such as underarms, neck, under breasts, and genital areas. The condition may result in psychological stress.
It runs in families and generally appears in adolescence, although may present in later adulthood. It is due to mutations in structural/desmosomal proteins found within stratified squamous epithelium. DDD is associated with KRT5. Diagnosis is by visualisation and skin biopsy. It may appear similar to reticulate acropigmentation of Kitamura, Haber syndrome, neurofibromatosis type 1, and acanthosis nigricans.
Treatments tried include applying hydroquinone, tretinoin, adapalene, and corticosteroids, but are generally unsuccessful. Applying corticosteroids and fusidic acid after Er:YAG laser has been reported to be successful in some reports.
It is rare. Since the first report in 1938, there have been less than 50 cases described.
Signs and symptoms
- ↑ 1.0 1.1 1.2 1.3 1.4 James, William D.; Elston, Dirk; Treat, James R.; Rosenbach, Misha A.; Neuhaus, Isaac (2020). "36. Disturbances of pigmentation: Dowling–Degos disease". Andrews' Diseases of the Skin: Clinical Dermatology (13th ed.). Edinburgh: Elsevier. p. 866. ISBN 978-0-323-54753-6.
- ↑ 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 2.11 Rice, Ashley S.; Cook, Christopher (2023). "Dowling Degos Disease". StatPearls. StatPearls Publishing. PMID 30285365. Archived from the original on 2021-04-03. Retrieved 2023-05-05.
- ↑ Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 978-1-4160-2999-1.
- ↑ Adya, Keshavmurthy A; Inamadar, Arun C; Palit, Aparna (2014). "Reticulate Dermatoses". Indian Journal of Dermatology. 59 (1): 3–14. doi:10.4103/0019-5154.123480. ISSN 0019-5154. PMID 24470653. Archived from the original on 2022-08-17. Retrieved 2023-05-05.