40S ribosomal protein S4, X isoform

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RPS4X
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesRPS4X, CCG2, DXS306, RPS4, S4, SCAR, SCR10, ribosomal protein S4, X-linked, ribosomal protein S4 X-linked
External IDsOMIM: 312760 HomoloGene: 90857 GeneCards: RPS4X
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001007

n/a

RefSeq (protein)

NP_000998

n/a

Location (UCSC)Chr X: 72.26 – 72.28 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

40S ribosomal protein S4, X isoform is a protein that in humans is encoded by the RPS4X gene.[3][4][5]

Ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes ribosomal protein S4, a component of the 40S subunit. Ribosomal protein S4 is the only ribosomal protein known to be encoded by more than one gene, namely this gene and ribosomal protein S4, Y-linked (RPS4Y). The 2 isoforms encoded by these genes are not identical, but are functionally equivalent. Ribosomal protein S4 belongs to the S4E family of ribosomal proteins. This gene is not subject to X-inactivation. It has been suggested that haploinsufficiency of the ribosomal protein S4 genes plays a role in Turner syndrome; however, this hypothesis is controversial. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000198034 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Watanabe M, Furuno N, Goebl M, Go M, Miyauchi K, Sekiguchi T, Basilico C, Nishimito T (Apr 1992). "Molecular cloning of the human gene, CCG2, that complements the BHK-derived temperature-sensitive cell cycle mutant tsBN63: identity of CCG2 with the human X chromosomal SCAR/RPS4X gene". J Cell Sci. 100 (1): 35–43. doi:10.1242/jcs.100.1.35. PMID 1795030.
  4. ^ Zinn AR, Alagappan RK, Brown LG, Wool I, Page DC (Apr 1994). "Structure and function of ribosomal protein S4 genes on the human and mouse sex chromosomes". Mol Cell Biol. 14 (4): 2485–92. doi:10.1128/mcb.14.4.2485. PMC 358616. PMID 8139551.
  5. ^ a b "Entrez Gene: RPS4X ribosomal protein S4, X-linked".

Further reading