RHOBTB1

RHOBTB1
Identifiers
Aliases	RHOBTB1, Rho related BTB domain containing 1
External IDs	OMIM: 607351 MGI: 1916538 HomoloGene: 8892 GeneCards: RHOBTB1
Gene location (Human) Chr. Chromosome 10 (human) Band 10q21.2 Start 60,869,438 bp End 61,001,440 bp
Gene location (Mouse) Chr. Chromosome 10 (mouse) Band 10|10 B5.3 Start 68,987,264 bp End 69,127,621 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in vastus lateralis muscle Achilles tendon biceps brachii right uterine tube placenta cardia triceps brachii muscle gastrocnemius muscle thoracic diaphragm pylorus Top expressed in myocardium of ventricle internal carotid artery cumulus cell aortic valve ascending aorta external carotid artery ureter islet of Langerhans otolith organ utricle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding GTP binding GTPase activity protein kinase binding Cellular component cytosol plasma membrane intracellular anatomical structure cytoplasm cytoskeleton cell projection Biological process regulation of small GTPase mediated signal transduction small GTPase mediated signal transduction cell morphogenesis actin filament organization Rho protein signal transduction cell migration actin cytoskeleton organization positive regulation of actin filament polymerization actin cytoskeleton reorganization engulfment of apoptotic cell Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9886 69288 Ensembl ENSG00000072422 ENSMUSG00000019944 UniProt O94844 Q9DAK3 RefSeq (mRNA) NM_001242359 NM_014836 NM_001350902 NM_001350903 NM_001350904 NM_001350905 NM_001350906 NM_001350907 NM_001350908 NM_001350909 NM_001350910 NM_001350911 NM_001081347 NM_001252636 NM_001252637 NM_001252638 RefSeq (protein) NP_001229288 NP_055651 NP_001337831 NP_001337832 NP_001337833 NP_001337834 NP_001337835 NP_001337836 NP_001337837 NP_001337838 NP_001337839 NP_001337840 NP_001229288.1 NP_055651.1 NP_001074816 NP_001239565 NP_001239566 NP_001239567 Location (UCSC) Chr 10: 60.87 – 61 Mb Chr 10: 68.99 – 69.13 Mb PubMed search
Wikidata
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Rho-related BTB domain-containing protein 1 is a protein that in humans is encoded by the RHOBTB1 gene.

The protein encoded by this gene belongs to the Rho family of the Ras superfamily of small GTPases. It contains a GTPase domain, a proline-rich region, a tandem of 2 BTB (broad complex, tramtrack, and bric-a-brac) domains, and a conserved C-terminal region. The protein plays a role in small GTPase-mediated signal transduction and the organization of the actin filament system. Alternate transcriptional splice variants have been characterized.

Further reading

• Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. CiteSeerX 10.1.1.529.4378. doi:10.1093/dnares/5.5.277. PMID 9872452.
• Ramos S, Khademi F, Somesh BP, Rivero F (2003). "Genomic organization and expression profile of the small GTPases of the RhoBTB family in human and mouse". Gene. 298 (2): 147–57. doi:10.1016/S0378-1119(02)00980-0. PMID 12426103.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Aspenström P, Fransson A, Saras J (2004). "Rho GTPases have diverse effects on the organization of the actin filament system". Biochem. J. 377 (Pt 2): 327–37. doi:10.1042/BJ20031041. PMC 1223866. PMID 14521508.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Beder LB, Gunduz M, Ouchida M, et al. (2006). "Identification of a candidate tumor suppressor gene RHOBTB1 located at a novel allelic loss region 10q21 in head and neck cancer" (PDF). J. Cancer Res. Clin. Oncol. 132 (1): 19–27. doi:10.1007/s00432-005-0033-0. PMID 16170569. S2CID 35193238.