RAC2

RAC2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1DS6, 2W2T, 2W2V, 2W2X
Identifiers
Aliases	RAC2, EN-7, Gx, HSPC022, p21-Rac2, ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2), Rac family small GTPase 2, IMD73B, IMD73C, IMD73A
External IDs	OMIM: 602049 MGI: 97846 HomoloGene: 55699 GeneCards: RAC2
Gene location (Human)
Chr.	Chromosome 22 (human)
End	37,244,448 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	78,456,983 bp
RNA expression pattern
	Top expressed in
	blood; ; spleen; ; bone marrow; ; bone marrow cells; ; appendix; ; monocyte; ; spongy bone; ; thymus; ; lymph node; ; periodontal fiber;
	Top expressed in
	thymus; ; spleen; ; blood; ; ankle joint; ; bone marrow; ; duodenum; ; dermis; ; subcutaneous adipose tissue; ; submandibular gland; ; body of femur;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; GTP binding; protein kinase regulator activity; GTPase activity; protein binding;
Cellular component	cytoplasm; cytosol; phagocytic vesicle membrane; nuclear envelope; membrane; focal adhesion; plasma membrane; actin filament; extracellular exosome; lamellipodium; intracellular anatomical structure;
Biological process	regulation of respiratory burst; lymphocyte aggregation; regulation of T cell proliferation; positive regulation of protein targeting to mitochondrion; regulation of hydrogen peroxide metabolic process; actin filament organization; regulation of cell-substrate adhesion; regulation of neutrophil migration; bone resorption; platelet activation; chemotaxis; cell projection assembly; positive regulation of cell population proliferation; regulation of mast cell chemotaxis; positive regulation of neutrophil chemotaxis; regulation of mast cell degranulation; regulation of protein kinase activity; positive regulation of lamellipodium assembly; regulation of small GTPase mediated signal transduction; actin cytoskeleton organization; signal transduction; small GTPase mediated signal transduction; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	5880
	19354
	ENSG00000128340
	ENSMUSG00000033220
	P15153
	Q05144
	NM_002872
	NM_009008
	NP_002863
	NP_033034
	Wikidata
View/Edit Human	View/Edit Mouse

Rac2 (Ras-related C3 botulinum toxin substrate 2) is a small (~21 kDa) signaling G protein (to be specific, a GTPase), and is a member of the Rac subfamily of the family Rho family of GTPases.^[5] It is encoded by the gene RAC2.^[6]

Members of Rho family of GTPases appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases.^[6]

Interactions

Rac2 has been shown to interact with ARHGDIA^[7]^[8] and Nitric oxide synthase 2A.^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000128340 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000033220 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ridley AJ (2006). "Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking". Trends Cell Biol. 16 (10): 522–9. doi:10.1016/j.tcb.2006.08.006. PMID 16949823.
^ ^a ^b "Entrez Gene: RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)".
^ Gorvel JP, Chang TC, Boretto J, Azuma T, Chavrier P (January 1998). "Differential properties of D4/LyGDI versus RhoGDI: phosphorylation and rho GTPase selectivity". FEBS Lett. 422 (2): 269–73. doi:10.1016/S0014-5793(98)00020-9. PMID 9490022. S2CID 10817327.
^ Fauré J, Dagher MC (May 2001). "Interactions between Rho GTPases and Rho GDP dissociation inhibitor (Rho-GDI)". Biochimie. 83 (5): 409–14. doi:10.1016/S0300-9084(01)01263-9. PMID 11368848.
^ Kuncewicz T, Balakrishnan P, Snuggs MB, Kone BC (August 2001). "Specific association of nitric oxide synthase-2 with Rac isoforms in activated murine macrophages". Am. J. Physiol. Renal Physiol. 281 (2): F326-36. doi:10.1152/ajprenal.2001.281.2.F326. PMID 11457725. S2CID 15719851.

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Gorvel JP, Chang TC, Boretto J, Azuma T, Chavrier P (1998). "Differential properties of D4/LyGDI versus RhoGDI: phosphorylation and rho GTPase selectivity". FEBS Lett. 422 (2): 269–73. doi:10.1016/S0014-5793(98)00020-9. PMID 9490022. S2CID 10817327.
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