Puumala orthohantavirus

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Puumala orthohantavirus
Virus classification e
(unranked): Virus
Realm: Riboviria
Kingdom: Orthornavirae
Phylum: Negarnaviricota
Class: Ellioviricetes
Order: Bunyavirales
Family: Hantaviridae
Genus: Orthohantavirus
Puumala orthohantavirus

Puumala orthohantavirus (PUUV) is a species of Orthohantavirus. Humans infected with the virus may develop a haemorrhagic fever with renal syndrome (HFRS) known as nephropathia epidemica. Puumala orthohantavirus HFRS is lethal in less than 0.5% of the cases.[1] Rarely, PUUV infection can cause Guillain-Barré syndrome.[2]

Puumala orthohantavirus was discovered and named in 1980 named after Puumala, a municipality in Finland.[3] The virus is found predominantly in Scandinavia and Finland, although it has also been reported elsewhere in Northern Europe, Poland and Russia. Because the bank vole (Myodes glareolus) acts as a reservoir for the virus, nephropathia epidemica cases track with the vole population in a three- to four-year cycle. Humans are infected through inhalation of dust from vole droppings.[4]It has been theorized that Puumala orthohantavirus, unlike other members of the genus Orthohantavirus, may also have lethal effects on its rodent host.[5]

In August 2014 an Israeli researcher studying the behavior of the bank vole in Finland died after contracting the Puumala orthohantavirus, which caused a complete breakdown of her immune system.[6]

Map of Puumala orthohantavirus infections in infected people in Austria, 2009–2019


  1. Discertation for doctoral exam; Distribution of Puumalavirus in Sweden Archived 2012-05-07 at the Wayback Machine, by C. Ahlm, second paragraph; latest access 2012-06-04
  2. Tassart G, Balbeur S, Deltombe T, Tintillier M, Cuvelier C (2014). "Guillain-Barré syndrome associated with Puumula Hantavirus infection". Acta Clin Belg. 69 (5): 371–374. doi:10.1179/0001551214Z.00000000085. PMID 25092197. S2CID 206837075.
  3. Brummer-Korvenkontio, M.; Vaheri, A.; Hovi, T.; Von Bonsdorff, C. H.; Vuorimies, J.; Manni, T.; Penttinen, K.; Oker-Blom, N.; Lähdevirta, J. (1980). "Nephropathia epidemica: detection of antigen in bank voles and serologic diagnosis of human infection". The Journal of Infectious Diseases. 141 (2): 131–134. doi:10.1093/infdis/141.2.131. PMID 6102587.
  4. Rose A, Vapalahti O, Lyytikäinen O, Nuorti P (January 2003). "Patterns of Puumala virus infection in Finland". Euro Surveill. 8 (1): 9–13. doi:10.2807/esm.08.01.00394-en. PMID 12631978.
  5. Kallio ER, Voutilainen L, Vapalahti O, Vaheri A, Henttonen H, Koskela E, Mappes T (August 2007). "Endemic hantavirus infection impairs the winter survival of its rodent host". Ecology. 88 (8): 1911–6. doi:10.1890/06-1620.1. PMID 17824420.
  6. קלנר, ירון (8 July 2014). "קרן חקרה מכרסמים - שגרמו למותה מנגיף אלים". Ynet. Archived from the original on 29 January 2020. Retrieved 26 October 2022.