Pseudohypoxia refers to increased cytosolic ratio of free NAD to NADH in cells, caused by hyperglycemia. Research has shown that declining levels of NAD+ during aging cause pseudohypoxia, and that raising nuclear NAD+ in old mice reverses pseudohypoxia and metabolic dysfunction, thus reversing the aging process. It is expected that human NAD trials will begin in 2014.
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-  Archived 2019-09-23 at the Wayback Machine Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging, Cell, Dec 2013
-  Archived 2016-12-21 at the Wayback Machine Guardian Newspaper - Online, Dec 2013