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Pseudohypoxia refers to increased cytosolic ratio of free NAD to NADH in cells, caused by hyperglycemia.[1] Research has shown that declining levels of NAD+ during aging cause pseudohypoxia, and that raising nuclear NAD+ in old mice reverses pseudohypoxia and metabolic dysfunction, thus reversing the aging process.[2] It is expected that human NAD trials will begin in 2014.[3]

Pseudohypoxia is a feature commonly noted in poorly-controlled diabetes.[1]

See also


  1. 1.0 1.1 [1] Archived 2018-07-05 at the Wayback Machine Diabetes Magazine: Hyperglycemic Pseudohypoxia and Diabetic Complications, March 12, 1993
  2. [2] Archived 2019-09-23 at the Wayback Machine Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging, Cell, Dec 2013
  3. [3] Archived 2016-12-21 at the Wayback Machine Guardian Newspaper - Online, Dec 2013