|Main uses||Tuberculosis, leprosy|
|Side effects||Headache, metallic taste, dry mouth, nausea|
|Chemical and physical data|
|Molar mass||180.27 g·mol−1|
|3D model (JSmol)|
Protionamide, also spelling prothionamide, is an antibiotic used to treat tuberculosis and leprosy. Specifically it is used in multi-drug resistant tuberculosis when other treatment, such as clofazimine, are not suitable. It is used together with other antituberculosis medication. It is taken by mouth for up to two years.
Common side effects include headache, metallic taste, dry mouth, and nausea. Other side effects may include liver problems. Alcohol should be avoided when it is used. Safety in pregnancy and breastfeeding is unclear. It is chemically similar to ethionamide.
Protionamide was discovered in 1956. It is not available in the United Kingdom or United States. It is on the World Health Organization's List of Essential Medicines as an alternative to ethionamide. It was relatively expensive in 2009.
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