Protein-glutamine glutaminase

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protein-glutamine glutaminase
Identifiers
EC no.3.5.1.44
CAS no.62213-11-0
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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PMCarticles
PubMedarticles
NCBIproteins

In enzymology, a protein-glutamine glutaminase (EC 3.5.1.44) is an enzyme that catalyzes the chemical reaction

protein L-glutamine + H2O protein L-glutamate + NH3

Thus, the two substrates of this enzyme are protein L-glutamine and H2O, whereas its two products are protein L-glutamate and NH3.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is protein-L-glutamine amidohydrolase. Other names in common use include peptidoglutaminase II, glutaminyl-peptide glutaminase, destabilase, and peptidylglutaminase II.

References

  • Kikuchi M, Hayashida H, Nakano E, Sakaguchi K (1971). "Peptidoglutaminase. Enzymes for selective deamidation of gamma-amide of peptide-bound glutamine". Biochemistry. 10 (7): 1222–9. doi:10.1021/bi00783a019. PMID 4928623.