Plasmepsin I
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| Plasmepsin I | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.4.23.38 | ||||||||
| CAS no. | 180189-87-1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Plasmepsin I (EC 3.4.23.38, aspartic hemoglobinase I, PFAPG, malaria aspartic hemoglobinase) is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction
- Hydrolysis of the -Phe33-Leu- bond in the alpha-chain of hemoglobin, leading to denaturation of the molecule
This enzyme is present in the malaria organism, Plasmodium.
References
- ^ Goldberg DE, Slater AF, Beavis R, Chait B, Cerami A, Henderson GB (April 1991). "Hemoglobin degradation in the human malaria pathogen Plasmodium falciparum: a catabolic pathway initiated by a specific aspartic protease". The Journal of Experimental Medicine. 173 (4): 961–9. doi:10.1084/jem.173.4.961. PMC 2190804. PMID 2007860.
- ^ Francis SE, Gluzman IY, Oksman A, Knickerbocker A, Mueller R, Bryant ML, Sherman DR, Russell DG, Goldberg DE (January 1994). "Molecular characterization and inhibition of a Plasmodium falciparum aspartic hemoglobinase". The EMBO Journal. 13 (2): 306–17. doi:10.1002/j.1460-2075.1994.tb06263.x. PMC 394809. PMID 8313875.
- ^ Gluzman IY, Francis SE, Oksman A, Smith CE, Duffin KL, Goldberg DE (April 1994). "Order and specificity of the Plasmodium falciparum hemoglobin degradation pathway". The Journal of Clinical Investigation. 93 (4): 1602–8. doi:10.1172/JCI117140. PMC 294190. PMID 8163662.
External links
- Plasmepsin+I at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
