Signaling peptide receptor

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Signaling peptide receptor is a type of receptor which binds one or more signaling peptides or signaling proteins.

An example is the tropomyosin receptor kinase B (TrkB), which is bound and activated by the neurotrophic protein brain-derived neurotrophic factor (BDNF). Another example is the μ-opioid receptor (MOR), which is bound and activated by the opioid peptide hormone β-endorphin.

Adiponectin receptor

AdipoR₁

Agonists
- Peptide
- Non-peptide
Antagonists
- Peptide
  - ADP-400

AdipoR₂

Agonists
- Peptide
- Non-peptide
Antagonists
- Peptide
  - ADP-400

Angiotensin receptor

Bradykinin receptor

Agonists
- Bradykinin
- Kallidin
Antagonists

Calcitonin gene-related peptide receptor

Agonists
- Amylin
- CGRP
- Pramlintide
Antagonists
- Atogepant
- BI 44370 TA
- CGRP (8-37)
- MK-3207
- Olcegepant
- Rimegepant
- SB-268262
- Telcagepant
- Ubrogepant
Antibodies

Cholecystokinin receptor

CCK_A

Agonists
- Cholecystokinin
Antagonists

CCK_B

Agonists
Antagonists

Unsorted

Antagonists
- Nastorazepide

Corticotropin-releasing hormone receptor

CRF₁

Agonists
Antagonists
- Antalarmin
- Astressin-B
- CP-154,526
- Emicerfont
- Hypericin
- LWH-234
- NBI-27914
- NBI-74788
- Pexacerfont
- R-121919
- TS-041
- Verucerfont

CRF₂

Agonists
Antagonists
- Astressin-B

Cytokine receptor

Endothelin receptor

Agonists
Antagonists
- A-192621
- Ambrisentan
- Aprocitentan
- Atrasentan
- Avosentan
- Bosentan
- BQ-123
- BQ-788
- Clazosentan
- Darusentan
- Edonentan
- Enrasentan
- Fandosentan
- Feloprentan
- Macitentan
- Nebentan
- Sitaxentan
- Sparsentan
- Tezosentan
- Zibotentan

Galanin receptor

GAL₁

Agonists
Antagonists
- C7
- Dithiepine-1,1,4,4-tetroxide
- Galantide (M15)
- M32
- M35
- M40
- SCH-202596

GAL₂

Agonists
- Galanin
- Galanin (1-15)
- Galanin (2-11)
- Galanin-like peptide
- Galmic
- Galnon
- J18
- NAX 810-2
Antagonists
- C7
- Galantide (M15)
- M32
- M35
- M40
- M871

GAL₃

Agonists
- Galanin
- Galanin (1-15)
- Galmic
- Galnon
Antagonists
- C7
- Galantide (M15)
- GalR3ant
- HT-2157
- M32
- M35
- M40
- SNAP-37889
- SNAP-398299

Growth hormone secretagogue receptor

Growth hormone receptor

Growth-hormone-releasing hormone receptor

Glucagon-like peptide receptor

GLP-1

Agonists

GLP-2

Agonists

Others

Propeptides
- Preproglucagon
- Proglucagon

Glucagon receptor

Agonists
Antagonists
Propeptides
- Preproglucagon
- Proglucagon

Gonadotropin-releasing hormone receptor

Gonadotropin receptor

Growth factor receptor

Insulin receptor

Agonists
Antagonists
- BMS-754807
- S661
- S961
Kinase inhibitors
- Linsitinib
Antibodies
- Xentuzumab (against IGF-1 and IGF-2)

KiSS1-derived peptide receptor

Agonists
Antagonists
- Kisspeptin-234

Leptin receptor

Agonists
- Leptin
- Metreleptin

Melanin-concentrating hormone receptor

MCH₁

Agonists
- Melanin-concentrating hormone
Antagonists
- ATC-0065
- ATC-0175
- GW-803430
- NGD-4715
- SNAP-7941
- SNAP-94847

MCH₂

Agonists
- Melanin-concentrating hormone

Melanocortin receptor

Neuropeptide FF receptor

Agonists
Antagonists
- BIBP-3226
- RF9

Neuropeptide S receptor

Agonists
- Neuropeptide S
Antagonists
- ML-154
- SHA-68

Neuropeptide Y receptor

Y₁

Agonists
- Neuropeptide Y
- Peptide YY
Antagonists
- BIBO-3304
- BIBP-3226
- BVD-10
- GR-231118
- PD-160170

Y₂

Agonists
Antagonists

Y₄

Agonists
Antagonists
- UR-AK49

Y₅

Agonists
Antagonists
- CGP-71683
- FMS-586
- L-152,804
- Lu AA-33810
- MK-0557
- NTNCB
- Velneperit (S-2367)

Neurotensin receptor

NTS₁

Agonists
- Neurotensin
- Neuromedin N
Antagonists
- Meclinertant
- SR-142948

NTS₂

Agonists
- Neurotensin
Antagonists
- Levocabastine
  - SR-142948

Opioid receptor

Orexin receptor

Oxytocin receptor

Prolactin receptor

Parathyroid hormone receptor

Agonists

Relaxin receptor

Agonists
- Insulin-like factor 3
- Relaxin (1, 2, 3)
- Serelaxin

Somatostatin receptor

Tachykinin receptor

Thyrotropin-releasing hormone receptor

Agonists

Thyrotropin receptor

Agonists
- Thyrotropin alfa
- TSH (thyrotropin)

Vasopressin receptor

Vasoactive intestinal peptide receptor and Pituitary adenylate cyclase-activating peptide

VIPR₁

Agonists
- Peptide
  - Bay 55-9837
  - LBT-3393
  - PACAP
  - VIP

VIPR₂

Agonists
- Peptide
  - LBT-3627
  - PACAP
  - VIP

PAC₁

Agonists
Antagonists
- PACAP (6-38)

Unsorted

Others

Endogenous
- Adrenomedullin
- Apelin
- Asprosin
- Bombesin
- Calcitonin
- Carnosine
- CART
- CLIP
- DSIP
- Enteroglucagon
- Formyl peptide
- GALP
- GIP
- GRP
- Integrin ligands
  - collagens
  - fibrinogen
  - fibronectin
  - laminins
  - ICAM-1
  - ICAM-2
  - osteopontin
  - VCAM-1
  - vitronectin
- Kininogens
- Motilin
- Natriuretic peptides
  - ANP
  - BNP
  - CNP
  - urodilatin
- Nesfatin-1
- Neuromedin B
- Neuromedin N
- Neuromedin S
- Neuromedin U
- Obestatin
- Osteocalcin
- Resistin
- Secretin
- Thymopoietin
- Thymosins
- Thymulin
- Urotensin-II
- VGF
Exogenous
- Lifitegrast (LFA-1 antagonist)

See also

References

External links

Peptide+receptor at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

Cell surface receptor: G protein-coupled receptors

Class A: Rhodopsin-like

Neurotransmitter

Adrenergic	α1 (A B D) α2 (A B C) β1 β2 β3
Purinergic	Adenosine (A1 A2A A2B A3) P2Y (1 2 4 5 6 8 9 10 11 12 13 14)
Serotonin	(all but 5-HT3) 5-HT1 (A B D E F) 5-HT2 (A B C) 5-HT (4 5A 6 7)
Other	Acetylcholine (M1 M2 M3 M4 M5) Dopamine D1 D2 D3 D4 D5 GHB receptor Histamine H1 H2 H3 H4 Melatonin (1A 1B 1C) TAAR (1 2 5 6 8 9)

Metabolites and
signaling molecules

Eicosanoid	CysLT (1 2) LTB4 1 2 FPRL1 OXE Prostaglandin DP (1 2), EP (1 2 3 4), FP Prostacyclin Thromboxane
Other	Bile acid Cannabinoid (CB1 CB2, GPR (18 55 119)) EBI2 Estrogen Free fatty acid (1 2 3 4) Hydroxycarboxylic acids 1 2 3 Lysophosphatidic acid (1 2 3 4 5 6) Lysophospholipid (1 2 3 4 5 6 7 8) Oxoglutarate PAF Sphingosine-1-phosphate (1 2 3 4 5) Succinate

Peptide

B/W (1
2)
FF (1
2)
S
Y (1
2
4
5)
Neuromedin (B
U (1
2))
Neurotensin (1
2)

Other

Miscellaneous

Taste, bitter	TAS2R 1 3 4 5 7 8 9 10 13 14 16 19 20 30 31 38 39 40 41 42 43 45 46 50 60 Vomeronasal receptor type 1
Orphan	GPR (1 3 4 6 12 15 17 18 19 20 21 22 23 25 26 27 31 32 33 34 35 37 39 42 44 45 50 52 55 61 62 63 65 68 75 78 81 82 83 84 85 87 88 92 101 103 109A 109B 119 120 132 135 137B 139 141 142 146 148 149 150 151 152 153 160 161 162 171 173 174 176 177 182 183)
Other	Adrenomedullin Olfactory Opsin (3 4 5 1LW 1MW 1SW RGR RRH) Protease-activated (1 2 3 4) SREB (1 2 3)

Class B: Secretin-like

Adhesion	ADGRB Brain-specific angiogenesis inhibitor 1 2 3 ADGRC Cadherin 1 2 3 ADGRE EMR 1 2 3 CD97 ADGRG 1 2 3 4 5 6 7 ADGRL Latrophilin 1 2 3 ELTD1
Orphan	GPR (56 64 97 98 110 111 112 113 114 115 116 123 124 125 126 128 133 143 144 155 157)
Other	Calcitonin CALCRL Corticotropin-releasing hormone (1 2) Glucagon (GR GIPR GLP1R GLP2R) Growth-hormone-releasing hormone PACAPR1 GPR Methuselah-like proteins Parathyroid hormone (1 2) Secretin Vasoactive intestinal peptide (1 2)

Class C: Metabotropic glutamate / pheromone

Taste, sweet	TAS1R 1 2 3 Vomeronasal receptor, type 2
Other	Calcium-sensing receptor GABA_B (1 2) Glutamate receptor (Metabotropic glutamate (1 2 3 4 5 6 7 8)) GPRC6A GPR (156 158 179) RAIG (1 2 3 4)

Class F: Frizzled & Smoothened

Frizzled	Frizzled (1 2 3 4 5 6 7 8 9 10)
Smoothened	Smoothened

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