Pancreatic serous cystadenoma

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Pancreatic serous cystadenoma
Other names: Serous cystadenoma of the pancreas, serous microcystic adenoma
Anatomy of the pancreas
SpecialtyGeneral surgery, gastroenterology
SymptomsUsually asymptomatic
Usual onset50–60 years of age
Risk factorsFemale gender
TreatmentSurgical resection (if symptomatic)

Pancreatic serous cystadenoma is a tumour of the pancreas.[2][3] It is typically noncancerous, solitary, and found when investigating something else.[3] One third of pancreatic cysts are serous cystadenomas.[3]

It is usually found in the body or tail of the pancreas, and may be associated with von Hippel–Lindau syndrome.[3]

It mostly affects females aged between 50-years and 70-years.[3]

Signs and symptoms

In most cases, serous cystadenomas of the pancreas are asymptomatic.[4] However, large cysts may cause symptoms related to their size.[4]


Pathologists classify serous cystic neoplasms into two broad groups. Those that are benign, that have not spread to other organs, are designated "serous cystadenoma".[5] Serous cystadenomas can be further sub-typed into microcystic, oligocystic (or macrocystic), solid, mixed serous-endocrine neoplasm, and VHL-associated serous cystic neoplasm. This latter classification scheme is useful because it highlights the range of appearances and the clinical associations of these neoplasms. Serous cystic neoplasms that have spread ("metastasized") to another organ are considered malignant and are designated "serous cystadenocarcinoma".[citation needed]



These lesions rarely require surgery unless they are symptomatic or the diagnosis is in question. Since these lesions do not have malignant potential, long-term observation with imaging surveillance is unnecessary.[4] Surgery can include the removal of the head of the pancreas (a pancreaticoduodenectomy), removal of the body and tail of the pancreas (a distal pancreatectomy), or rarely removal of the entire pancreas (a total pancreatectomy).[6] In selected cases the surgery can be performed using minimally invasive techniques such as laparoscopy.[7]


Serous cystadenomas of the pancreas are more common in women.[4] SCAs are usually diagnosed in people 50–60 years of age.[4]

In contrast to some of the other cyst-forming tumors of the pancreas (such as the intraductal papillary mucinous neoplasm and the pancreatic mucinous cystadenoma), serous cystic neoplasms are almost always entirely benign. There are some exceptions; rare case reports have described isolated malignant serous cystadenocarcinomas.[8] In addition, serous cystic neoplasms slowly grow, and if they grow large enough they can press on adjacent organs and cause symptoms.

See also


  1. Jais B, Rebours V, Malleo G, Salvia R, Fontana M, Maggino L, et al. (February 2016). "Serous cystic neoplasm of the pancreas: a multinational study of 2622 patients under the auspices of the International Association of Pancreatology and European Pancreatic Club (European Study Group on Cystic Tumors of the Pancreas)". Gut. 65 (2): 305–312. doi:10.1136/gutjnl-2015-309638. hdl:11577/3187425. PMID 26045140.
  2. WHO Classification of Tumours Editorial Board (2019). "10. Tumours of the pancreas: Pancreatic serous cystadenoma". Digestive System Tumours. Vol. 1 (5th ed.). Lyon (France). pp. 303–306. ISBN 978-92-832-4499-8. Archived from the original on 2022-06-13. Retrieved 2023-04-26.
  3. 3.0 3.1 3.2 3.3 3.4 Dababneh, Yara; Mousa, Omar Y. (2022). "Pancreatic Serous Cystadenoma". StatPearls. StatPearls Publishing. Archived from the original on 2022-07-05. Retrieved 2022-07-02.
  4. 4.0 4.1 4.2 4.3 4.4 Elta GH, Enestvedt BK, Sauer BG, Lennon AM (April 2018). "ACG Clinical Guideline: Diagnosis and Management of Pancreatic Cysts". The American Journal of Gastroenterology. 113 (4): 464–479. doi:10.1038/ajg.2018.14. PMID 29485131. S2CID 3584079.
  5. "Pathology of Neoplasms of the Pancreas". Johns Hopkins University. Archived from the original on 13 March 2020. Retrieved 25 April 2010.
  6. "Pancreatic Surgery". Johns Hopkins University. Archived from the original on 23 February 2020. Retrieved 25 April 2010.
  7. "Laproscopic Pancreatic Surgery". Johns Hopkins University. Archived from the original on 4 December 2019. Retrieved 25 April 2010.
  8. Galanis C, Zamani A, Cameron JL, Campbell KA, Lillemoe KD, Caparrelli D, et al. (July 2007). "Resected serous cystic neoplasms of the pancreas: a review of 158 patients with recommendations for treatment". Journal of Gastrointestinal Surgery. 11 (7): 820–826. doi:10.1007/s11605-007-0157-4. PMID 17440789. S2CID 32023143.

External links

External resources