PRKCH

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PRKCH
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPRKCH, PKC-L, PKCL, PRKCL, nPKC-eta, protein kinase C eta
External IDsOMIM: 605437 MGI: 97600 HomoloGene: 84384 GeneCards: PRKCH
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006255

NM_008856
NM_001313977

RefSeq (protein)

NP_006246

NP_001300906
NP_032882

Location (UCSC)Chr 14: 61.19 – 61.55 MbChr 12: 73.63 – 73.82 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein kinase C eta type is an enzyme that in humans is encoded by the PRKCH gene.[5][6][7]

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipids-dependent protein kinase. It is predominantly expressed in epithelial tissues and has been shown to reside specifically in the cell nucleus. This protein kinase can regulate keratinocyte differentiation by activating the MAP kinase MAPK13 (p38delta)-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha (CEBPA). It is also found to mediate the transcription activation of the transglutaminase 1 (TGM1) gene.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000027075 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021108 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Bacher N, Zisman Y, Berent E, Livneh E (Feb 1991). "Isolation and characterization of PKC-L, a new member of the protein kinase C-related gene family specifically expressed in lung, skin, and heart". Mol Cell Biol. 11 (1): 126–33. doi:10.1128/mcb.11.1.126-133.1991. PMC 359602. PMID 1986216.
  6. ^ Bacher N, Zisman Y, Berent E, Livneh E (Apr 1992). "Isolation and characterization of PKC-L, a new member of the protein kinase C-related gene family specifically expressed in lung, skin, and heart". Mol Cell Biol. 12 (3): 1404. doi:10.1128/mcb.12.3.1404-.1992. PMC 369574. PMID 1545821.
  7. ^ a b "Entrez Gene: PRKCH protein kinase C, eta".

Further reading