POLD3

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POLD3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPOLD3, P66, P68, PPP1R128, polymerase (DNA) delta 3, accessory subunit, DNA polymerase delta 3, accessory subunit
External IDsOMIM: 611415 MGI: 1915217 HomoloGene: 38202 GeneCards: POLD3
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006591
NM_001363597

NM_133692
NM_001368380

RefSeq (protein)

NP_006582
NP_001350526

NP_598453
NP_001355309

Location (UCSC)Chr 11: 74.49 – 74.67 MbChr 7: 99.73 – 99.77 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

DNA polymerase delta subunit 3 is an enzyme that in humans is encoded by the POLD3 gene.[5][6] It is a component of the DNA polymerase delta complex.

Interactions

POLD3 has been shown to interact with PCNA.[7][8]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000077514 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030726 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hughes P, Tratner I, Ducoux M, Piard K, Baldacci G (Jun 1999). "Isolation and identification of the third subunit of mammalian DNA polymerase delta by PCNA-affinity chromatography of mouse FM3A cell extracts". Nucleic Acids Res. 27 (10): 2108–14. doi:10.1093/nar/27.10.2108. PMC 148430. PMID 10219083.
  6. ^ "Entrez Gene: POLD3 polymerase (DNA-directed), delta 3, accessory subunit".
  7. ^ Ducoux M, Urbach S, Baldacci G, Hübscher U, Koundrioukoff S, Christensen J, Hughes P (Dec 2001). "Mediation of proliferating cell nuclear antigen (PCNA)-dependent DNA replication through a conserved p21(Cip1)-like PCNA-binding motif present in the third subunit of human DNA polymerase delta". J. Biol. Chem. 276 (52): 49258–66. doi:10.1074/jbc.M106990200. PMID 11595739.
  8. ^ Ohta S, Shiomi Y, Sugimoto K, Obuse C, Tsurimoto T (Oct 2002). "A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein". J. Biol. Chem. 277 (43): 40362–7. doi:10.1074/jbc.M206194200. PMID 12171929.

Further reading