Ozenoxacin

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Ozenoxacin
Ozenoxacin.svg
Names
Pronunciationoz en ox' a sin
Trade namesOzanex; Xepi
  • 1-Cyclopropyl-8-methyl-7-[5-methyl-6-(methylamino)-3-pyridinyl]-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid
Clinical data
Drug classAntibiotic (quinolone)[1]
Main usesImpetigo[1]
Side effectsUncommon[2]
Pregnancy
category
  • US: N (Not classified yet)
Routes of
use
Topical
External links
AHFS/Drugs.comMonograph
US NLMOzenoxacin
MedlinePlusa618010
Legal
License data
Legal status
Chemical and physical data
FormulaC21H21N3O3
Molar mass363.417 g·mol−1
3D model (JSmol)
  • O=C\3c1c(c(c(cc1)c2cc(c(nc2)NC)C)C)N(/C=C/3C(=O)O)C4CC4
  • InChI=1S/C21H21N3O3/c1-11-8-13(9-23-20(11)22-3)15-6-7-16-18(12(15)2)24(14-4-5-14)10-17(19(16)25)21(26)27/h6-10,14H,4-5H2,1-3H3,(H,22,23)(H,26,27)
  • Key:XPIJWUTXQAGSLK-UHFFFAOYSA-N

Ozenoxacin, sold under the brand names Ozanex and Xepi, is an antibiotic used to treat impetigo.[1] This includes impetigo due to methicillin-resistant S. aureus (MRSA).[2] It is applied to the skin as a cream.[2]

As little is absorbed through the skin; side effects are uncommon.[2] Side effects may include seborrheic dermatitis.[4] It is not expected to be harmful in pregnancy or breastfeeding.[1] It is a quinolone and works by blocking DNA gyrase A and topoisomerase IV.[1]

Ozenoxacin was approved for medical use in the United States and Canada in 2017.[1][5] In the United States a 30 gram tube of 1% cream costs about 340 USD as of 2021.[6] This amount in Canada costs about 53 CAD.[7]

Medical use

Ozenoxacin is used to treat impetigo caused by S. aureus and S. pyogenes .[2] It may also be used to get rid of methicillin-resistant S. aureus (MRSA).[2]

Dosage

It is used as a 1% cream applied twice daily for 5 days in those over the age of 2 months.[2]

References

  1. 1.0 1.1 1.2 1.3 1.4 1.5 "DailyMed - XEPI- ozenoxacin cream". dailymed.nlm.nih.gov. Archived from the original on 11 November 2021. Retrieved 10 November 2021.
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 Robertson, Dirk B.; Maibach, Howard I. (2020). "61. Dermatologic pharmacology". In Katzung, Bertram G.; Trevor, Anthony J. (eds.). Basic and Clinical Pharmacology (15th ed.). New York: McGraw-Hill. p. 1112. ISBN 978-1-260-45231-0. Archived from the original on 2021-10-10. Retrieved 2021-11-07.
  3. "Xepi- ozenoxacin cream". DailyMed. 30 January 2020. Archived from the original on 17 October 2020. Retrieved 13 October 2020.
  4. "Ozenoxacin Monograph for Professionals". Drugs.com. Archived from the original on 15 October 2020. Retrieved 10 November 2021.
  5. Canada, Health (30 June 2017). "Notice: Prescription Drug List (PDL): Multiple Additions [2017-06-23]". www.canada.ca. Archived from the original on 8 July 2021. Retrieved 10 November 2021.
  6. "Xepi Prices, Coupons & Patient Assistance Programs". Drugs.com. Retrieved 10 November 2021.
  7. "Pharmacoeconomic Review Report" (PDF). CADTH. Archived (PDF) from the original on 19 October 2019. Retrieved 10 November 2021.

External links

External sites:
Identifiers: