Serous cystadenoma of the ovary

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Ovarian serous cystadenoma
Ovarian serous cystadenoma. The cystic space is at the top of the image. Ovarian parenchyma is seen at the bottom right. H&E stain.
PrognosisCan recur after excision[1]

Ovarian serous cystadenoma is a noncancerous type of tumor of the ovary.[1] It is typically larger than 1cm in diameter and presents with signs and symptoms of a growth in the pelvis or is discovered when investigating something else.[1][2] A fifth occur in both ovaries at the same time.[2]

It is a type of serous tumor of the ovary made up of cells that look similar to fallopian tube epithelium.[1]

Test include ultrasound or colour doppler study to know about size and nature of mass and sometimes CECT. Blood investigation includes CA-125 level for screening and further CEA, beta hCG levels, AFP, CA19-9, LDH level to confirm diagnosis.[citation needed]

It is the most common ovarian neoplasm, representing 20% of ovarian neoplasms.[3]


Serous cystadenomas are diagnosed by histomorphologic examination, by pathologists. Grossly, they are, usually, small unilocular cysts that contain clear, straw-coloured fluid. However, they may sometimes be multilocular. Microscopically, the cyst lining consists of a simple epithelium, whose cells may be either:[4]

  • be columnar and tall and contain cilia, resembling normal tubal epithelium
  • be cuboidal and have no cilia, resembling ovarian surface epithelium

Microscopical images


Ovarian serous cystadenoma accounts for the largest proportion of benign ovarian tumours, making up over 50–80% of all benign epithelial ovarian tumours. Its prevalence peaks between 60–70 years of the human lifespan. Serous ovarian cystadenocarcinomas account for ~25% of serous tumours.[5]

See also


  1. 1.0 1.1 1.2 1.3 1.4 1.5 WHO Classification of Tumours Editorial Board, ed. (2020). "1. Tumours of the ovary: serous cystadenoma, adenofibroma, and surface papilloma of the ovary". Female genital tumours: WHO Classification of Tumours. Vol. 4 (5th ed.). Lyon (France): International Agency for Research on Cancer. pp. 36–37. ISBN 978-92-832-4504-9. Archived from the original on 2022-06-17. Retrieved 2022-06-29.
  2. 2.0 2.1 Rashid, Sameera; Arafah, Maria A.; Akhtar, Mohammed (1 May 2022). "The Many Faces of Serous Neoplasms and Related Lesions of the Female Pelvis: A Review". Advances in Anatomic Pathology. 29 (3): 154–167. doi:10.1097/PAP.0000000000000334. ISSN 1533-4031. Archived from the original on 29 July 2022. Retrieved 29 July 2022.
  3. Peterson CM (1997). "Common Causes of Ovarian Enlargement: Ovarian neoplasms". Human Reproduction. University of Utah Medpath. Archived from the original on 2022-06-18. Retrieved 2022-06-29.
  4. Ehdaivand S. "Ovary tumor - serous tumors - Serous cystadenoma / adenofibroma / surface papilloma". Pathology Outlines. Archived from the original on 2020-02-24. Retrieved 2022-06-29. Topic Completed: 1 June 2012. Revised: 5 March 2020
  5. Radswiki. "Ovarian serous cystadenocarcinoma". | Radiology Reference Article. Archived from the original on 2019-07-11. Retrieved 2019-09-21.

External links