ORG-21465
(Redirected from Org 21465)
Jump to navigation
Jump to search
Clinical data | |
---|---|
Other names | 2β-(2,2-Dimethyl-4-morpholinyl)-3α-hydroxy-11,20-dioxo-5α-pregnan-21-yl methanesulfonate |
Identifiers | |
| |
PubChem CID | |
ChemSpider | |
Chemical and physical data | |
Formula | C27H43NO7S |
Molar mass | 525.70 g·mol−1 |
3D model (JSmol) | |
| |
| |
(verify) |
ORG-21465 is a synthetic neuroactive steroid, with sedative effects resulting from its action as a GABAA receptor positive allosteric modulator. It is similar to related drugs such as ORG-20599, and was similarly developed as an improved alternative to other sedative steroids such as althesin and allopregnanolone, which despite its superior properties in some respects has not proved to offer enough advantages to be accepted into clinical use.[1][2]
Chemistry
See also
References
- ^ Sear JW (October 1997). "ORG 21465, a new water-soluble steroid hypnotic: more of the same or something different?". British Journal of Anaesthesia. 79 (4): 417–9. doi:10.1093/bja/79.4.417. PMID 9389254.
- ^ Vanlersberghe C, Camu F (2008). "Etomidate and other non-barbiturates". Modern Anesthetics. Handbook of Experimental Pharmacology. Vol. 182. pp. 267–82. doi:10.1007/978-3-540-74806-9_13. ISBN 978-3-540-72813-9. PMID 18175096.
Categories:
- Articles with short description
- Short description matches Wikidata
- Chemical articles without CAS registry number
- Articles without EBI source
- Chemical pages without DrugBank identifier
- Articles without KEGG source
- Articles without UNII source
- Drugs missing an ATC code
- Drugs with no legal status
- Neurosteroids
- Anticonvulsants
- Hypnotics
- Morpholines
- GABAA receptor positive allosteric modulators
- Pregnanes
- All stub articles
- Sedative stubs