Nolatrexed

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Nolatrexed
Names
Preferred IUPAC name
2-Amino-6-methyl-5-[(pyridin-4-yl)sulfanyl]quinazolin-4(1H)-one
Identifiers
3D model (JSmol)
ChemSpider
UNII
  • InChI=1S/C14H12N4OS/c1-8-2-3-10-11(13(19)18-14(15)17-10)12(8)20-9-4-6-16-7-5-9/h2-7H,1H3,(H3,15,17,18,19) ☒N
    Key: XHWRWCSCBDLOLM-UHFFFAOYSA-N ☒N
  • InChI=1/C14H12N4OS/c1-8-2-3-10-11(13(19)18-14(15)17-10)12(8)20-9-4-6-16-7-5-9/h2-7H,1H3,(H3,15,17,18,19)
    Key: XHWRWCSCBDLOLM-UHFFFAOYAK
  • CC1=C(C2=C(C=C1)NC(=NC2=O)N)SC3=CC=NC=C3
Properties
C14H12N4OS
Molar mass 284.34 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Nolatrexed is a thymidylate synthase inhibitor.[1][2]

References

  1. ^ Hughes AN, Rafi I, Griffin MJ, et al. (January 1999). "Phase I studies with the nonclassical antifolate nolatrexed dihydrochloride (AG337, THYMITAQ) administered orally for 5 days". Clin. Cancer Res. 5 (1): 111–8. PMID 9918208.
  2. ^ "Nolatrexed". PubChem.gov. Pub Chem. Retrieved 12 August 2014.


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