Nacolomab tafenatox

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Nacolomab tafenatox
Monoclonal antibody
TypeFab fragment
SourceMouse
Targetcolorectal tumor antigen C242
Clinical data
ATC code
  • none
Identifiers
CAS Number
ChemSpider
  • none
UNII
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Nacolomab tafenatox is a mouse monoclonal antibody.[1][2] The antibody itself, nacolomab, is fused with enterotoxin A from Staphylococcus aureus (which is reflected by 'tafenatox' in the drug's name).[1]

Schematic image of nacolomab tafenatox.
VH, VL: variable (antigen binding) domains of antibody fragment
CH1, CL: constant domains of antibody fragment
SAg: enterotoxin A (acting as a superantigen)

See also

References

  1. ^ a b "Recommended INN List: Nacolomab tafenatox" (PDF). WHO Drug Information. 9 (3): 182. 1995.
  2. ^ Alpaugh RK, Weiner LM, Persson B, Persson R, Dohlsten M, Kalland T (1997). "Nacolomab Tafenatox". Drugs of the future. 22 (11): 1226–30.