NRXN3

NRXN3
Identifiers
Aliases	NRXN3, C14orf60, neurexin 3
External IDs	OMIM: 600567 GeneCards: NRXN3
Gene location (Human) Chr. Chromosome 14 (human) Band 14q24.3-q31.1 Start 78,170,373 bp End 79,868,291 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar vermis pons Brodmann area 23 cerebellar hemisphere middle temporal gyrus superior vestibular nucleus external globus pallidus parietal lobe superior frontal gyrus postcentral gyrus n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function neuroligin family protein binding transmembrane signaling receptor activity cell adhesion molecule binding metal ion binding signaling receptor activity Cellular component integral component of membrane membrane plasma membrane integral component of plasma membrane Biological process neuron cell-cell adhesion social behavior vocalization behavior adult behavior cell adhesion learning angiogenesis signal transduction axon guidance positive regulation of synapse assembly positive regulation of synapse maturation synapse assembly neurotransmitter secretion chemical synaptic transmission Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9369 n/a Ensembl ENSG00000021645 n/a UniProt Q9HDB5 n/a RefSeq (mRNA) NM_001105250 NM_001272020 NM_004796 NM_138970 NM_001330195 NM_001366425 NM_001366426 n/a RefSeq (protein) NP_001098720 NP_001258949 NP_001317124 NP_004787 NP_620426 NP_001353354 NP_001353355 NP_004787.2 n/a Location (UCSC) Chr 14: 78.17 – 79.87 Mb n/a PubMed search n/a
Wikidata
View/Edit Human

Neurexin-3-alpha is a protein that in humans is encoded by the NRXN3 gene.

Neurexins are a family of proteins that function in the vertebrate nervous system as cell adhesion molecules and receptors. They are encoded by several unlinked genes of which two, NRXN1 and NRXN3, are among the largest known human genes. Three of the genes (NRXN1-3) utilize two alternate promoters and include numerous alternatively spliced exons to generate thousands of distinct mRNA transcripts and protein isoforms. The majority of transcripts are produced from the upstream promoter and encode alpha-neurexin isoforms; a much smaller number of transcripts are produced from the downstream promoter and encode beta-neurexin isoforms. The alpha-neurexins contain epidermal growth factor-like (EGF-like) sequences and laminin G domains, and have been shown to interact with neurexophilins. The beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins. NRXN3 is thought to be involved in synaptic plasticity, and polymorphisms in NRXN3 have been linked to genetic predisposition towards a number of conditions such as alcohol or drug addiction, or obesity.

Further reading

• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Heilig R, Eckenberg R, Petit JL, et al. (2003). "The DNA sequence and analysis of human chromosome 14". Nature. 421 (6923): 601–7. Bibcode:2003Natur.421..601H. doi:10.1038/nature01348. PMID 12508121.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Tabuchi K, Südhof TC (2002). "Structure and evolution of neurexin genes: insight into the mechanism of alternative splicing". Genomics. 79 (6): 849–59. doi:10.1006/geno.2002.6780. PMID 12036300.
• Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
• Hock B, Böhme B, Karn T, et al. (1998). "PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor". Proc. Natl. Acad. Sci. U.S.A. 95 (17): 9779–84. Bibcode:1998PNAS...95.9779H. doi:10.1073/pnas.95.17.9779. PMC 21413. PMID 9707552.
• Nagase T, Ishikawa K, Miyajima N, et al. (1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581.
• Hata Y, Butz S, Südhof TC (1996). "CASK: a novel dlg/PSD95 homolog with an N-terminal calmodulin-dependent protein kinase domain identified by interaction with neurexins". J. Neurosci. 16 (8): 2488–94. doi:10.1523/JNEUROSCI.16-08-02488.1996. PMC 6578772. PMID 8786425.
• Ichtchenko K, Nguyen T, Südhof TC (1996). "Structures, alternative splicing, and neurexin binding of multiple neuroligins". J. Biol. Chem. 271 (5): 2676–82. doi:10.1074/jbc.271.5.2676. PMID 8576240.
• Ushkaryov YA, Petrenko AG, Geppert M, Südhof TC (1992). "Neurexins: synaptic cell surface proteins related to the alpha-latrotoxin receptor and laminin". Science. 257 (5066): 50–6. Bibcode:1992Sci...257...50U. doi:10.1126/science.1621094. PMID 1621094.