NPR1

From WikiProjectMed
Jump to navigation Jump to search
NPR1
Identifiers
AliasesNPR1, ANPRA, ANPa, GUC2A, GUCY2A, NPRA, natriuretic peptide receptor 1
External IDsOMIM: 108960 MGI: 97371 HomoloGene: 37367 GeneCards: NPR1
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000906

NM_008727

RefSeq (protein)

NP_000897

NP_032753

Location (UCSC)Chr 1: 153.68 – 153.69 MbChr 3: 90.36 – 90.37 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A), also known as NPR1, is an atrial natriuretic peptide receptor. In humans it is encoded by the NPR1 gene.

Function

NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP and BNP, respectively).[5]

It is localized in the kidney[6] where it results in natriuresis upon binding to natriuretic peptides. However, it is found in even greater quantity in the lungs and adipocytes.[6]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000169418 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027931 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: NPR1 natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)".
  6. ^ a b BioGPS > NPR1 Retrieved Nov 2010 Archived November 27, 2010, at the Wayback Machine

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.