Protein-coding gene in the species Homo sapiens
Neuronal growth regulator 1 also known as NEGR1 is a protein which in humans is encoded by the NEGR1 gene .[5]
Clinical significance Variants of the NEGR1 gene may be associated with obesity and major depression.[6] [7] [8]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000172260 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040037 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Funatsu N, Miyata S, Kumanogoh H, Shigeta M, Hamada K, Endo Y, Sokawa Y, Maekawa S (March 1999). "Characterization of a novel rat brain glycosylphosphatidylinositol-anchored protein (Kilon), a member of the IgLON cell adhesion molecule family" . J. Biol. Chem . 274 (12): 8224–30. doi :10.1074/jbc.274.12.8224 PMID 10075727 . ^ Thorleifsson G, Walters GB, Gudbjartsson DF, et al. (January 2009). "Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity". Nat. Genet . 41 (1): 18–24. doi :10.1038/ng.274 . PMID 19079260 . S2CID 764409 . ^ Willer CJ, Speliotes EK, Loos RJ, et al. (January 2009). "Six new loci associated with body mass index highlight a neuronal influence on body weight regulation" . Nat. Genet . 41 (1): 24–34. doi :10.1038/ng.287 . PMC 2695662 PMID 19079261 . ^ Zhao J, Bradfield JP, Li M, et al. (May 2009). "The role of obesity-associated loci identified in genome wide association studies in the determination of pediatric BMI" . Obesity (Silver Spring) . 17 (12): 2254–7. doi :10.1038/oby.2009.159 . PMC 2860782 PMID 19478790 .
Further reading
Elortza F, Mohammed S, Bunkenborg J, et al. (2006). "Modification-specific proteomics of plasma membrane proteins: identification and characterization of glycosylphosphatidylinositol-anchored proteins released upon phospholipase D treatment". J. Proteome Res . 5 (4): 935–43. doi :10.1021/pr050419u . PMID 16602701 . Haupt A, Thamer C, Heni M, et al. (2009). "Novel Obesity Risk Loci Do Not Determine Distribution of Body Fat Depots: A Whole-body MRI/MRS study" . Obesity (Silver Spring) . 18 (6): 1212–7. doi :10.1038/oby.2009.413 PMID 19910938 . Li S, Zhao JH, Luan J, et al. (2010). "Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studies" . Am. J. Clin. Nutr . 91 (1): 184–90. doi :10.3945/ajcn.2009.28403 PMID 19812171 . Brandys MK, van Elburg AA, Loos RJ, et al. (2010). "Are recently identified genetic variants regulating BMI in the general population associated with anorexia nervosa?". Am. J. Med. Genet. B Neuropsychiatr. Genet . 153B (2): 695–9. doi :10.1002/ajmg.b.31026 . PMID 19746409 . S2CID 45793585 . Renström F, Payne F, Nordström A, et al. (2009). "Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden" . Hum. Mol. Genet . 18 (8): 1489–96. doi :10.1093/hmg/ddp041 . PMC 2664142 PMID 19164386 . Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1" . Nature . 441 (7091): 315–21. Bibcode :2006Natur.441..315G . doi :10.1038/nature04727 PMID 16710414 . Bauer F, Elbers CC, Adan RA, et al. (2009). "Obesity genes identified in genome-wide association studies are associated with adiposity measures and potentially with nutrient-specific food preference" . Am. J. Clin. Nutr . 90 (4): 951–9. doi :10.3945/ajcn.2009.27781 PMID 19692490 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Hom G, Graham RR, Modrek B, et al. (2008). "Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX" . N. Engl. J. Med . 358 (9): 900–9. doi :10.1056/NEJMoa0707865 PMID 18204098 . Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment" . Genome Res . 13 (10): 2265–70. doi :10.1101/gr.1293003 . PMC 403697 PMID 12975309 . Yang Q, Kathiresan S, Lin JP, et al. (2007). "Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study" . BMC Med. Genet . 8 (Suppl 1): S12. doi :10.1186/1471-2350-8-S1-S12 PMC 1995619 PMID 17903294 . Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Hotta K, Nakamura M, Nakamura T, et al. (2009). "Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population" . J. Hum. Genet . 54 (12): 727–31. doi :10.1038/jhg.2009.106 PMID 19851340 . Thorleifsson G, Walters GB, Gudbjartsson DF, et al. (2009). "Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity". Nat. Genet . 41 (1): 18–24. doi :10.1038/ng.274 . PMID 19079260 . S2CID 764409 .
