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Morbilliform (drug eruption)

A morbilliform eruption refers to a rash that looks like measles.[1] It typically appears as small blanching, pink to red spots and bumps, that merge in some places.[1] There maybe an associated mild itch.[2] It is different to a rash that is urticarial, eczematous, psoriasiform, pustular, vesicular, or vasculitic.[1] The term is frequently used interchangeably with maculopapular rash.[1]


People with measles will have the rash but there are other syndromes and infections that will display the same symptom such as people with Kawasaki disease,[3] meningococcal petechiae or Waterhouse-Friderichsen syndrome,[3] Dengue, Roseola, congenital syphilis,[4] rubella,[3] Echovirus 9,[3] drug hypersensitivity reactions (in particular with certain classes of antiretroviral drugs, such as abacavir and nevirapine, and also the antiepileptic drug phenytoin), or other conditions may also have a morbilliform rash. It has also been mentioned as a possible manifestation of onset or recovery from COVID-19.[5]

One cause of morbilliform rash is an allergic reaction to transfused blood/blood components. In such a case, the skin lesions would develop within a few hours (Approx. 4hours) of transfusion along with pruritus. The condition may even present with other symptoms, such as conjunctival oedema, oedema in the lips and tongue, and even localised angioedema. On rare occasions, the condition may even escalate to anaphylactic shock where pulmonary restrictions are seen. The associated cause for this is a reaction against an allergen that is seldom identified during testing. Transfusing products with anti-IgA antibodies to IgA-deficient patients has also been a suspected cause for such reactions. Management usually relates to the stoppage of transfusion for around 30minutes, until given antihistamines take effect. Transfusion may even be continued after, if no further progression is seen.

See also


  1. 1.0 1.1 1.2 1.3 Haber, Jessica S.; Cipriano, Sarah D.; Oza, Vikash S. (April 2022). "Morbilliform Eruptions in the Hospitalized Child". Dermatologic Clinics. 40 (2): 191–202. doi:10.1016/j.det.2021.12.006. ISSN 0733-8635. PMID 35366972. Archived from the original on 2024-03-08. Retrieved 2024-03-08.
  2. Morris-Jones, Rachel (2019). "10. The skin and systemic disease". In Morris-Jones, Rachael (ed.). ABC of Dermatology (7th ed.). Hoboken: Wiley Blackwell. pp. 75–77. ISBN 978-1-119-48899-6. Archived from the original on 2024-03-08. Retrieved 2024-03-08.
  3. 3.0 3.1 3.2 3.3 > morbilliform rash Archived 2018-07-22 at the Wayback Machine Retrieved on Nov 30, 2009
  4. American Family Physician Sept 1st 2012 Vol 86 No 5 pp381-482 Syphilis: A re-emerging infection.
  5. "Archive copy". Archived from the original on 2020-12-18. Retrieved 2020-12-17.{{cite web}}: CS1 maint: archived copy as title (link)

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