Microsomal triglyceride transfer protein

MTTP
Identifiers
Aliases	MTTP, ABL, MTP, Microsomal triglyceride transfer protein
External IDs	OMIM: 157147 MGI: 106926 HomoloGene: 212 GeneCards: MTTP
Gene location (Human) Chr. Chromosome 4 (human) Band 4q23 Start 99,564,081 bp End 99,623,997 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3 G3|3 64.06 cM Start 137,795,615 bp End 137,850,729 bp
RNA expression pattern Bgee Top expressed in jejunal mucosa liver duodenum Right lobe of liver kidney tubule kidney testicle Ganglionic eminence metanephric glomerulus gallbladder More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein heterodimerization activity GO:0001948 protein binding phospholipid transporter activity lipid binding lipid transporter activity Cellular component receptor complex endoplasmic reticulum lumen endoplasmic reticulum Golgi apparatus basolateral plasma membrane Biological process phospholipid transport lipid transport plasma lipoprotein particle assembly lipid metabolism protein secretion triglyceride transport chylomicron assembly very-low-density lipoprotein particle assembly lipoprotein metabolic process cholesterol homeostasis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4547	17777
Ensembl	ENSG00000138823	ENSMUSG00000028158
UniProt	P55157	O08601
RefSeq (mRNA)	NM_001300785 NM_000253 NM_001386140	NM_001163457 NM_008642 NM_001355051 NM_001355052
RefSeq (protein)	NP_000244 NP_001287714	NP_001156929 NP_032668 NP_001341980 NP_001341981
Location (UCSC)	Chr 4: 99.56 – 99.62 Mb	Chr 3: 137.8 – 137.85 Mb
PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Microsomal triglyceride transfer protein large subunit is a protein that in humans is encoded by the MTTP gene.

MTP encodes the large subunit of the heterodimeric microsomal triglyceride transfer protein. Protein disulfide isomerase (PDI) completes the heterodimeric microsomal triaglyceride transfer protein, which has been shown to play a central role in lipoprotein assembly. Mutations in MTP can cause abetalipoproteinemia.

Apolipoprotein B48 on chylomicra and Apolipoprotein B100 on LDL, IDL, and VLDL are important for MTP binding.

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.

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Statin Pathway edit

Pharmacology

Drugs that inhibit MTTP prevent the assembly of apo B-containing lipoproteins thus inhibiting the synthesis of chylomicrons and VLDL and leading to decrease in plasma levels of LDL-C.

• Lomitapide (Juxtapid) was approved by the US FDA for adjunctive treatment of homozygous familial hypercholesterolemia.
• Dirlotapide (Slentrol) and mitratapide (Yarvitan) are veterinary drugs for the management of obesity in dogs.

Further reading

• Luz JM, Lennarz WJ (1996). Protein disulfide isomerase: a multifunctional protein of the endoplasmic reticulum. EXS. Vol. 77. pp. 97–117. doi:10.1007/978-3-0348-9088-5_7. ISBN 978-3-0348-9901-7. PMID 8856971.
• Wetterau JR, Lin MC, Jamil H (1997). "Microsomal triaglyceride transfer protein". Biochim. Biophys. Acta. 1345 (2): 136–50. doi:10.1016/s0005-2760(96)00168-3. PMID 9106493.
• Gordon DA (1997). "Recent advances in elucidating the role of the microsomal triaglyceride transfer protein in apolipoprotein B lipoprotein assembly". Curr. Opin. Lipidol. 8 (3): 131–7. doi:10.1097/00041433-199706000-00002. PMID 9211060.
• Ye J (2007). "Reliance of Host Cholesterol Metabolic Pathways for the Life Cycle of Hepatitis C Virus". PLOS Pathog. 3 (8): e108. doi:10.1371/journal.ppat.0030108. PMC 1959368. PMID 17784784.
• Wetterau JR, Aggerbeck LP, Bouma ME, et al. (1992). "Absence of microsomal triaglyceride transfer protein in individuals with abetalipoproteinemia". Science. 258 (5084): 999–1001. Bibcode:1992Sci...258..999W. doi:10.1126/science.1439810. PMID 1439810.
• Sharp D, Ricci B, Kienzle B, et al. (1994). "Human microsomal triaglyceride transfer protein large subunit gene structure". Biochemistry. 33 (31): 9057–61. doi:10.1021/bi00197a005. PMID 7545943.
• Shoulders CC, Narcisi TM, Read J, et al. (1995). "The abetalipoproteinemia gene is a member of the vitellogenin family and encodes an alpha-helical domain". Nat. Struct. Biol. 1 (5): 285–6. doi:10.1038/nsb0594-285. PMID 7664034. S2CID 11860468.
• Hagan DL, Kienzle B, Jamil H, Hariharan N (1994). "Transcriptional regulation of human and hamster microsomal triaglyceride transfer protein genes. Cell type-specific expression and response to metabolic regulators". J. Biol. Chem. 269 (46): 28737–44. PMID 7961826.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Sharp D, Blinderman L, Combs KA, et al. (1993). "Cloning and gene defects in microsomal triaglyceride transfer protein associated with abetalipoproteinaemia". Nature. 365 (6441): 65–9. Bibcode:1993Natur.365...65S. doi:10.1038/365065a0. PMID 8361539. S2CID 4334532.
• Narcisi TM, Shoulders CC, Chester SA, et al. (1996). "Mutations of the Microsomal Triglyceride-Transfer–Protein Gene in Abetalipoproteinemia". Am. J. Hum. Genet. 57 (6): 1298–310. PMC 1801399. PMID 8533758.
• Rehberg EF, Samson-Bouma ME, Kienzle B, et al. (1997). "A novel abetalipoproteinemia genotype. Identification of a missense mutation in the 97-kDa subunit of the microsomal triaglyceride transfer protein that prevents complex formation with protein disulfide isomerase". J. Biol. Chem. 271 (47): 29945–52. doi:10.1074/jbc.271.47.29945. PMID 8939939.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Linnik KM, Herscovitz H (1998). "Multiple molecular chaperones interact with apolipoprotein B during its maturation. The network of endoplasmic reticulum-resident chaperones (ERp72, GRP94, calreticulin, and BiP) interacts with apolipoprotein b regardless of its lipidation state". J. Biol. Chem. 273 (33): 21368–73. doi:10.1074/jbc.273.33.21368. PMID 9694898.
• Bradbury P, Mann CJ, Köchl S, et al. (1999). "A common binding site on the microsomal triaglyceride transfer protein for apolipoprotein B and protein disulfide isomerase". J. Biol. Chem. 274 (5): 3159–64. doi:10.1074/jbc.274.5.3159. PMID 9915855.
• Wang J, Hegele RA (2000). "Microsomal triaglyceride transfer protein (MTP) gene mutations in Canadian subjects with abetalipoproteinemia". Hum. Mutat. 15 (3): 294–5. doi:10.1002/(SICI)1098-1004(200003)15:3<294::AID-HUMU14>3.0.CO;2-E. PMID 10679949.