Michael M. Gottesman

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Michael M. Gottesman
Born (1946-10-07) October 7, 1946 (age 77)
Jersey City, New Jersey, U.S.
EducationHarvard University
Known forImpact of silent polymorphisms on tertiary structure and function
AwardsNational Academy of Sciences
Scientific career
FieldsBiochemistry
InstitutionsPeter Dent Brigham Hospital, Boston; Harvard University; National Institutes of Health

Michael M. Gottesman (born October 7, 1946, in Jersey City, New Jersey[1]) is an American biochemist and physician-scientist. He was the deputy director (Intramural) of the National Institutes of Health (NIH) in the United States, and also Chief of the Laboratory of Cell Biology at the National Cancer Institute (NCI) within the NIH.[2]

Career

He graduated summa cum laude in biochemical sciences in 1966 from Harvard College, and received his M.D. magna cum laude from Harvard Medical School in 1970.[1] He then worked as an intern and resident at the Peter Dent Brigham Hospital in Boston, a research associate at the NIH, and an assistant professor at Harvard before taking a permanent position at the NIH in 1976.[1] On August 1, 2022, Gottesman was succeeded as director of the NIH Intramural Research Program by pediatric neurologist Nina F. Schor.[3]

Research

His areas of expertise includes a major contribution to the discovery of P-glycoprotein (MDR1, ABCB1), the multidrug resistance efflux transporter associated with clinical resistance to anti-cancer agents.[4][5] In 2007, he reported for the first time in Science magazine that silent polymorphisms can impact on the tertiary structure and function of a protein.[6]

Distinctions

Gottesman is an elected member of the American Association for the Advancement of Science (1988), the National Academy of Medicine (2003), the Association of American Physicians (2006), the American Academy of Arts and Sciences (2010), and the National Academy of Sciences (2018).

References

  1. ^ a b c Pharmacology Conference Speakers Archived January 16, 2009, at the Wayback Machine, Office of Research on Women's Health. Accessed April 20, 2023. "Michael Marc Gottesman was born on October 7, 1946 in Jersey City, New Jersey, and grew up in Flushing, New York."
  2. ^ Staff profile Archived 2010-05-27 at the Wayback Machine, NCI, retrieved 2010-02-28.
  3. ^ "Dr. Nina Schor appointed as the NIH Acting Deputy Director for Intramural Research". National Institutes of Health (NIH). 2022-07-13. Retrieved 2022-07-29.
  4. ^ Chen, Chang-jie; Chin, Janice E.; Ueda, Kazumitsu; Clark, Douglas P.; Pastan, Ira; Gottesman, Michael M.; Roninson, Igor B. (1986), "Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells", Cell, 47 (3): 381–389, doi:10.1016/0092-8674(86)90595-7, PMID 2876781, S2CID 20431107.
  5. ^ Thiebaut, F.; Tsuruo, T.; Hamada, H.; Gottesman, M. M.; Pastan, I.; Willingham, M. C. (1987), "Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues", Proceedings of the National Academy of Sciences, 84 (21): 7735–7738, Bibcode:1987PNAS...84.7735T, doi:10.1073/pnas.84.21.7735, PMC 299375, PMID 2444983.
  6. ^ Kimchi-Sarfaty, Chava; Oh, Jung Mi; Kim, In-Wha; Sauna, Zuben E.; Calcagno, Anna Maria; Ambudkar, Suresh V.; Gottesman, Michael M. (2007), "A "silent" polymorphism in the MDR1 gene changes substrate specificity", Science, 315 (5811): 525–528, Bibcode:2007Sci...315..525K, doi:10.1126/science.1135308, PMID 17185560, S2CID 15146955.

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