Megazol
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| Formula | C6H6N6O2S |
| Molar mass | 226.21 g·mol−1 |
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Megazol (CL 64855) is a nitroimidazole based drug that cures some protozoan infections.
A study of nitroimidazoles found the drug extremely effective against T. cruzi and T. brucei which cause Chagas disease and African sleeping sickness, respectively. The drug is considerably more effective than standard benznidazole therapy (for Chagas) which is considered the gold standard.[1] This is despite that other nitroimidazoles proved ineffective against these pathogens.[citation needed]
References
- ^ Hall BS, Wilkinson SR (January 2012). "Activation of benznidazole by trypanosomal type I nitroreductases results in glyoxal formation". Antimicrobial Agents and Chemotherapy. 56 (1): 115–23. doi:10.1128/AAC.05135-11. PMC 3256028. PMID 22037852.
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