Lusutrombopag

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Lusutrombopag
Lusutrombopag.svg
Names
Pronunciationloo" soo trom' boe pag
Trade namesMulpleta, Mulpleo, Lusutrombopag Shionogi, others
  • (E)-3-[2,6-Dichloro-4-[[4-[3-[(1S)-1-hexoxyethyl]-2-methoxyphenyl]-1,3-thiazol-2-yl]carbamoyl]phenyl]-2-methylprop-2-enoic acid
Clinical data
Drug classThrombopoietin receptor agonist[1]
Main usesLow platelets due to chronic liver disease[2]
Side effectsHeadache, nausea, portal vein thrombosis, rash[2][3]
Pregnancy
category
  • US: N (Not classified yet)
Routes of
use
By mouth
Typical dose3 mg OD[1]
External links
AHFS/Drugs.comMonograph
US NLMLusutrombopag
MedlinePlusa618043
Legal
License data
Legal status
  • US: ℞-only
  • EU: Rx-only
  • In general: ℞ (Prescription only)
Chemical and physical data
FormulaC29H32Cl2N2O5S
Molar mass591.54 g·mol−1
3D model (JSmol)
  • CCCCCCO[C@@H](C)c1cccc(-c2csc(NC(=O)c3cc(Cl)c(/C=C(\C)C(=O)O)c(Cl)c3)n2)c1OC
  • InChI=1S/C29H32Cl2N2O5S/c1-5-6-7-8-12-38-18(3)20-10-9-11-21(26(20)37-4)25-16-39-29(32-25)33-27(34)19-14-23(30)22(24(31)15-19)13-17(2)28(35)36/h9-11,13-16,18H,5-8,12H2,1-4H3,(H,35,36)(H,32,33,34)/b17-13+/t18-/m0/s1 checkY
  • Key:NOZIJMHMKORZBA-KJCUYJGMSA-N checkY

Lusutrombopag, sold under the brand name Mulpleta among others, is a medication used to treat low platelets due to chronic liver disease.[2] It is used before surgery.[1] It is taken by mouth.[1]

Common side effects include headache.[2] Other side effects may include nausea, portal vein thrombosis, and rash.[3] It is a thrombopoietin receptor agonist which increases platelet numbers.[1][3]

Lusutrombopag was approved in the United States in 2018 and Europe in 2019.[2][3] In the United Kingdom a course of treatment costs the NHS about £800.[1] In the United States this amount costs about 8,900 USD.[4]

Medical uses

Dosage

It is taken as 3 mg per day for 7 days before surgery.[1]

References

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1080. ISBN 978-0857114105.
  2. 2.0 2.1 2.2 2.3 2.4 "Lusutrombopag Monograph for Professionals". Drugs.com. Archived from the original on 17 June 2020. Retrieved 24 November 2021.
  3. 3.0 3.1 3.2 3.3 "Mulpleo EPAR". European Medicines Agency (EMA). Archived from the original on 17 June 2020. Retrieved 17 June 2020.
  4. "Mulpleta Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 16 April 2021. Retrieved 24 November 2021.

External links

External sites:
Identifiers: