Lusutrombopag

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Lusutrombopag
Lusutrombopag.svg
Names
Pronunciationloo" soo trom' boe pag
Trade namesMulpleta, Mulpleo, Lusutrombopag Shionogi, others
  • (E)-3-[2,6-Dichloro-4-[[4-[3-[(1S)-1-hexoxyethyl]-2-methoxyphenyl]-1,3-thiazol-2-yl]carbamoyl]phenyl]-2-methylprop-2-enoic acid
Clinical data
Drug classThrombopoietin receptor agonist[1]
Main usesLow platelets due to chronic liver disease[2]
Side effectsHeadache, nausea, portal vein thrombosis, rash[2][3]
Pregnancy
category
  • US: N (Not classified yet)
Routes of
use
By mouth
Typical dose3 mg OD[1]
External links
AHFS/Drugs.comMonograph
US NLMLusutrombopag
MedlinePlusa618043
Legal
License data
Legal status
  • US: ℞-only
  • EU: Rx-only
  • In general: ℞ (Prescription only)
Chemical and physical data
FormulaC29H32Cl2N2O5S
Molar mass591.54 g·mol−1
3D model (JSmol)
  • CCCCCCO[C@@H](C)c1cccc(-c2csc(NC(=O)c3cc(Cl)c(/C=C(\C)C(=O)O)c(Cl)c3)n2)c1OC
  • InChI=1S/C29H32Cl2N2O5S/c1-5-6-7-8-12-38-18(3)20-10-9-11-21(26(20)37-4)25-16-39-29(32-25)33-27(34)19-14-23(30)22(24(31)15-19)13-17(2)28(35)36/h9-11,13-16,18H,5-8,12H2,1-4H3,(H,35,36)(H,32,33,34)/b17-13+/t18-/m0/s1 checkY
  • Key:NOZIJMHMKORZBA-KJCUYJGMSA-N checkY
 ☒NcheckY (what is this?)

Lusutrombopag, sold under the brand name Mulpleta among others, is a medication used to treat low platelets due to chronic liver disease.[2] It is used before surgery.[1] It is taken by mouth.[1]

Common side effects include headache.[2] Other side effects may include nausea, portal vein thrombosis, and rash.[3] It is a thrombopoietin receptor agonist which increases platelet numbers.[1][3]

Lusutrombopag was approved in the United States in 2018 and Europe in 2019.[2][3] In the United Kingdom a course of treatment costs the NHS about £800.[1] In the United States this amount costs about 8,900 USD.[4]

Medical uses

Dosage

It is taken as 3 mg per day for 7 days before surgery.[1]

References

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1080. ISBN 978-0857114105.
  2. 2.0 2.1 2.2 2.3 2.4 "Lusutrombopag Monograph for Professionals". Drugs.com. Retrieved 24 November 2021.
  3. 3.0 3.1 3.2 3.3 "Mulpleo EPAR". European Medicines Agency (EMA). Retrieved 17 June 2020.
  4. "Mulpleta Prices, Coupons & Patient Assistance Programs". Drugs.com. Retrieved 24 November 2021.

External links

External sites:
Identifiers: