Luliconazole

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Luliconazole
Luliconazole.svg
Luliconazole ball-and-stick model.png
Names
Trade namesLuzu, Luzarn, Lulicon, others
  • (2E)-[(4R)-4-(2,4-Dichlorophenyl)-1,3-dithiolan-2-ylidene](1H-imidazol-1-yl)acetonitrile
Clinical data
Drug classAntifungal (imidazole)[1]
Main usesAthlete's foot, jock itch, ringworm[2]
Side effectsItchiness, pain[1]
Routes of
use		Topical
External links
AHFS/Drugs.comMonograph
Legal
Legal status
  • In general: ℞ (Prescription only)
Pharmacokinetics
Protein binding>99%[3]
Chemical and physical data
FormulaC14H9Cl2N3S2
Molar mass354.27 g·mol−1
3D model (JSmol)
  • C1[C@H](S/C(=C(\C#N)/N2C=CN=C2)/S1)C3=C(C=C(C=C3)Cl)Cl
  • InChI=1S/C14H9Cl2N3S2/c15-9-1-2-10(11(16)5-9)13-7-20-14(21-13)12(6-17)19-4-3-18-8-19/h1-5,8,13H,7H2/b14-12+/t13-/m0/s1
  • Key:YTAOBBFIOAEMLL-REQDGWNSSA-N

Luliconazole, sold under the brand name Luzu among others, is a medication used to treat athlete's foot, jock itch, and ringworm.[2] It is applied to the area affected.[2]

Common side effects include itchiness and pain.[1] Other side effects may include contact dermatitis.[1] Safety in pregnancy and breastfeeding is unclear.[2] It is in the imidazole family of medications.[1]

Luliconazole was approved for medical use in the United States in 2013.[2] In the United States it costs about 490 USD for a 60 gram tube of cream as of 2021.[4]

Medical uses

Spectrum of activity

This includes dermatophytes such as Trichophyton rubrum and Epidermophyton floccosum.[3]

Dosage

It is used once per day for 1 to 2 weeks.[2] It comes as a 1% cream.[2]

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 "Luliconazole Monograph for Professionals". Drugs.com. Retrieved 24 November 2021.
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 "DailyMed - LULICONAZOLE cream". dailymed.nlm.nih.gov. Archived from the original on 11 December 2021. Retrieved 24 November 2021.
  3. ↑ 3.0 3.1 "LUZU (luliconazole) Cream, 1%. Full Prescribing Information" (PDF). Valeant Pharmaceuticals North America LLC. Archived (PDF) from the original on 4 March 2016. Retrieved 1 October 2015.
  4. ↑ "Luzu Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 29 September 2016. Retrieved 24 November 2021.

External links

Identifiers:
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