List of side effects of tramadol
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The most common side effects of tramadol in order of decreasing incidence are:[1][2][3][4][5][6][7]
Note: Serious adverse effects are in bold.
Very common (>10% frequency)
- Dizziness
- Nausea
- Constipation
- Vertigo
- Headache
- Vomiting
- Somnolence (drowsiness)
Common (1–10% frequency)
- Agitation
- Anxiety
- Emotional lability
- Euphoria
- Nervousness
- Spasticity
- Dyspepsia (indigestion)
- Asthenia (weakness)
- Pruritus (itchiness)
- Dry mouth
- Diarrhea
- Fatigue
- Sweating
- Malaise
- Vasodilation (dilation (widening) of blood vessels)
- Confusion
- Coordination disturbance
- Miosis
- Sleep disorder
- Rash
- Hypertonia
- Abdominal pain
- Weight loss
- Visual disturbance
- Flatulence
- Menopausal symptoms
- Urinary frequency
- Urinary retention (being unable to urinate)
Uncommon (0.1-1% incidence)
- Cardiovascular regulation anomalies (palpitation, tachycardia, postural hypotension or cardiovascular collapse)
- Retching
- Gastrointestinal irritation (a feeling of pressure in the stomach, bloating)
- Urticaria (hives)
- Trembling
- Flushing
Rare (0.01–0.1% incidence)
- Bradycardia
- Hypertension (high blood pressure)
- Allergic reactions (e.g. dyspnoea (shortness of breath), bronchospasm, wheezing, angioneurotic oedema)
- Anaphylaxis
- Changes in appetite
- Paraesthesia (pins and needles)
- Hallucinations
- Tremor
- Respiratory depression
- Epileptiform convulsions
- Involuntary muscle contractions
- Abnormal coordination
- Syncope (fainting)
- Blurred vision
- Dyspnoea (shortness of breath)
- Tinnitus (ringing in the ears)
- Migraine
- Stevens–Johnson syndrome/toxic epidermal necrolysis (potentially fatal skin reactions)
- Motorial weakness
- Creatinine increase
- Elevated liver enzymes
- Hepatitis (liver swelling)
- Stomatitis (mouth swelling)
- Liver failure
- Pulmonary oedema (fluid in the lungs)
- Gastrointestinal bleeding
- Pulmonary embolism
- Myocardial ischaemia (lack of blood supply to the heart muscles)
- Speech disorders
- Haemoglobin decrease
- Proteinuria (protein in the urine; usually indicative of kidney damage)
References
- ^ "Ultram, Ultram ER (tramadol) dosing, indications, interactions, adverse effects, and more". Medscape Reference. WebMD. Retrieved 28 November 2013.
- ^ "PRODUCT INFORMATION Tramadol SANDOZ 50 mg capsules" (PDF). TGA eBusiness Services. Sandoz Pty Ltd. 4 November 2011. Retrieved 6 April 2014.
- ^ "Tramadol Hydrochloride 50mg Capsules – Summary of Product Characteristics (SPC)". electronic Medicines Compendium. Actavis UK Ltd. 12 June 2013. Retrieved 28 November 2013.
- ^ "Tilodol SR 100 mg Prolonged-Release Tablets – Summary of Product Characteristics (SPC)". electronic Medicines Compendium. Sandoz Limited. 6 March 2013. Retrieved 28 November 2013.
- ^ "PRODUCT INFORMATION TRAMADOL SANDOZ SR 100MG, 150MG and 200MG SUSTAINED RELEASE TABLETS" (PDF). TGA eBusiness Services. Sandoz Pty Ltd. 21 November 2013. Retrieved 28 November 2013.
- ^ "ULTRAM (TRAMADOL HYDROCHLORIDE) TABLET, COATED [LAKE ERIE MEDICAL DBA QUALITY CARE PRODUCTS LLC]". DailyMed. LAKE ERIE MEDICAL DBA QUALITY CARE PRODUCTS LLC. November 2012. Retrieved 28 November 2013.
- ^ "ULTRAM ER (TRAMADOL HYDROCHLORIDE) TABLET, EXTENDED RELEASE [REBEL DISTRIBUTORS CORP]". DailyMed. Rebel Distributors Corp. December 2010. Retrieved 28 November 2013.