List of investigational antidepressants

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This is a list of investigational antidepressants, or antidepressants that are currently under development for clinical use in the treatment of mood disorders but are not yet approved. Chemical/generic names are listed first, with developmental code names, synonyms, and brand names in parentheses. All drugs listed are specifically under development for major depressive disorder (MDD) and/or treatment-resistant depression (TRD) unless noted otherwise. Other forms of depression may include bipolar depression and postpartum depression.

Drugs that have been investigated but are not currently in development as antidepressants are given in italic.

Glutamatergics

NMDA receptor modulators

AMPA receptor modulators

Monoaminergics

Monoamine reuptake inhibitors

Monoamine reuptake inhibitors and receptor modulators

Monoamine releasing agents

Monoamine receptor modulators

Atypical antipsychotics

  • Brilaroxazine (RP-5063, RP-5000) – AA – specifically under development for the treatment of MDD[17]
  • Lumateperone (ITI-007, Caplyta) – AA – specifically under development for the treatment of MDD and bipolar.[18] Has been approved to treat BP 1 and BP 2 disorder under the brand name Caplyta.[10]
  • Lurasidone (Latuda) – AA – specifically under development for the treatment of MDD [11]
  • Pimavanserin (Nuplazid; ACP-103; BVF-048) – 5-HT2A receptor antagonist – specifically under development for the treatment of MDD[19]

Others

GABAergics and neurosteroids

GABAA receptor positive modulators

  • Zuranolone (SAGE-217) – GABAA receptor positive allosteric modulator – specifically under development for the treatment of MDD and postpartum depression[21]

Others

Opioidergics

κ-Opioid receptor antagonists

Nociceptin receptor antagonists

Cholinergics

Muscarinic acetylcholine receptor modulators

Others

Orexin receptor antagonists

Others

Mixed

Combinations

Not under development

The following notable drugs are of investigational interest as potential antidepressants but are not formally under clinical development for approval at this time:

See also

References

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Further reading

External links