|Other names: Drug-induced lichen planus, drug-induced lichenoid eruption, lichenoid cutaneous drug reaction|
|Lichenoid reaction hand|
|Symptoms||Dry scaly reddish bumps or plaques, localised or generalised, often on sun-exposed part of body|
|Usual onset||few hours to several weeks after taking causative drug|
|Diagnostic method||History, visualisation, patch test, skin biopsy|
|Differential diagnosis||Lichen planus|
|Treatment||Identify and stop causative drug|
Lichenoid drug eruption is dry scaly reddish bumps or patches of the skin that typically appear after taking certain medicines. It often appears in a sun-exposed part of the body, particularly the arms and lips. It may be localised or generalised and the nails may be affected.
It looks similar to lichen planus. Though they have different shapes and lack the white streaks that lichen planus has. It can appear a few hours or weeks after exposure to the causative drug.
Medications that can cause the condition include gold, thiazide, beta blockers, ACE inhibitors, antimalarials, and griseofulvin. It can also occur with proton pump inhibitors and as a symptom of lupus such as subacute cutaneous lupus erythematous. It is characterized by damage and infiltration between the epidermis and dermis.
The term "lichenoid" derives from a resemblance to a lichen.
Signs and symptoms
Arsenic was the first drug to be noted to caused a lichenoid drug eruption.
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