Latanoprostene bunod

From WikiProjectMed
Jump to navigation Jump to search
Latanoprostene bunod
Latanoprostene bunod.svg
Trade namesVyzulta
Other namesBOL-303259-X
  • 4-Nitrooxybutyl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]hept-5-enoate
Clinical data
Drug classProstaglandin[1]
Main usesIncreased intraocular pressure[1]
Side effectsEye pain, eye redness[1]
External links
Legal status
Chemical and physical data
Molar mass507.624 g·mol−1
3D model (JSmol)
  • C1[C@H]([C@@H]([C@H]([C@H]1O)C/C=C\CCCC(=O)OCCCCO[N+](=O)[O-])CC[C@H](CCC2=CC=CC=C2)O)O
  • InChI=1S/C27H41NO8/c29-22(15-14-21-10-4-3-5-11-21)16-17-24-23(25(30)20-26(24)31)12-6-1-2-7-13-27(32)35-18-8-9-19-36-28(33)34/h1,3-6,10-11,22-26,29-31H,2,7-9,12-20H2/b6-1-/t22-,23+,24+,25-,26+/m0/s1

Latanoprostene bunod, sold under the brand name Vyzulta, is a medication used to treat increased intraocular pressure in open-angle glaucoma and ocular hypertension.[1] It is used as an eye drop.

Common side effects include eye pain and eye redness.[1] Other side effects may include bacterial keratitis, macular edema, darkening of the skin around the eye, and eyelash changes.[1] It is a prostaglandin which increases outflow through the trabecular meshwork and uveoscleral pathway.[1][2]

Latanoprostene bunod was approved for medical use in the United States in 2017.[1] In the United States it costs about 230 USD for a 2.5 ml bottle as of 2021.[3] As of 2021 it is not commercially available in the United Kingdom or Europe.[4]


  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 "Latanoprostene Bunod Monograph for Professionals". Archived from the original on 4 March 2021. Retrieved 21 November 2021.
  2. Hoy SM (May 2018). "Latanoprostene Bunod Ophthalmic Solution 0.024%: A Review in Open-Angle Glaucoma and Ocular Hypertension". Drugs. 78 (7): 773–780. doi:10.1007/s40265-018-0914-6. PMC 5976683. PMID 29761382.
  3. "Vyzulta Prices, Coupons & Patient Assistance Programs". Archived from the original on 16 May 2021. Retrieved 21 November 2021.
  4. "Latanoprostene bunod". SPS - Specialist Pharmacy Service. 25 January 2016. Archived from the original on 21 November 2021. Retrieved 21 November 2021.

External links