LMO3

From WikiProjectMed
Jump to navigation Jump to search
LMO3
Identifiers
AliasesLMO3, RBTN3, RBTNL2, RHOM3, Rhom-3, LIM domain only 3
External IDsOMIM: 180386 HomoloGene: 136507 GeneCards: LMO3
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

RefSeq (protein)

n/a

Location (UCSC)Chr 12: 16.55 – 16.61 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

LIM domain only protein 3 is a transcription co-factor, which in humans is encoded by the LMO3 gene.[3][4][5] LMO3 interacts with the tumor suppressor p53 and regulates its function.[6] LMO3 is considered to be an oncogene in Neuroblastoma.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000048540 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Larsen S, Yokochi T, Isogai E, Nakamura Y, Ozaki T, Nakagawara A (February 2010). "LMO3 interacts with p53 and inhibits its transcriptional activity". Biochemical and Biophysical Research Communications. 392 (3): 252–7. doi:10.1016/j.bbrc.2009.12.010. PMID 19995558.
  4. ^ Shi J, Cai W, Chen X, Ying K, Zhang K, Xie Y (August 2001). "Identification of dopamine responsive mRNAs in glial cells by suppression subtractive hybridization". Brain Research. 910 (1–2): 29–37. doi:10.1016/S0006-8993(01)02393-9. PMID 11489251. S2CID 43814085.
  5. ^ EntrezGene 55885
  6. ^ Larsen S, Yokochi T, Isogai E, Nakamura Y, Ozaki T, Nakagawara A (February 2010). "LMO3 interacts with p53 and inhibits its transcriptional activity". Biochemical and Biophysical Research Communications. 392 (3): 252–7. doi:10.1016/j.bbrc.2009.12.010. PMID 19995558.
  7. ^ Larsen S, Yokochi T, Isogai E, Nakamura Y, Ozaki T, Nakagawara A (February 2010). "LMO3 interacts with p53 and inhibits its transcriptional activity". Biochemical and Biophysical Research Communications. 392 (3): 252–7. doi:10.1016/j.bbrc.2009.12.010. PMID 19995558.

Further reading