|Signet ring cell carcinoma metastasis to the ovary, also called Krukenberg tumor: Gross pathology (top, cross-section at right) and histopathology at low and high magnification. The latter shows invasive proliferation of signet-ring cells with a desmoplastic stroma.|
A Krukenberg tumor refers to a malignancy in the ovary that metastasized from a primary site, classically the gastrointestinal tract, although it can arise in other tissues such as the breast. Gastric adenocarcinoma, especially at the pylorus, is the most common source. Krukenberg tumors are often (over 80%) found in both ovaries, consistent with its metastatic nature.
Signs and symptoms
Krukenberg tumors often come to the attention when they cause abdominal or pelvic pain, bloating, ascites, or pain during sexual intercourse. Krukenberg tumors can occasionally provoke a reaction of the ovarian stroma which leads to hormone production, that results in vaginal bleeding, a change in menstrual habits, or hirsutism, or occasionally virilization as a main symptom. In rare cases the disease can manifest with hydronephrosis and hydroureter.
All these symptoms are non-specific and can also arise with a range of problems other than cancer, and a diagnosis can only be made following confirmatory investigations such as computed tomography (CT) scans, laparotomy and/or a biopsy of the ovary.
Krukenberg tumors can be seen in all age groups, with an average age of 45 years. In most countries, cancer that has metastasized to the ovary accounts for only about 1 to 2% of ovarian cancer; in the remainder, the ovary itself is the primary cancer site. However, in Japan they represent a much higher percentage of malignancies in the ovary (almost 20%) due to the increased prevalence of gastric cancer.
There has been debate over the exact mechanism of metastasis of the tumor cells from the stomach, appendix or colon to the ovaries. Classically it was thought that direct seeding across the abdominal cavity accounted for the spread of this tumor, but spread by way of the lymphatic is considered more likely. Retrograde lymphatics are thought to be more important in the pathogenesis of Krukenberg tumour, since the ovaries in Krukenberg tumour do not show capsular invasion or a breech of the epithelium lining the surface. The average age of diagnosis of Krukenberg tumors may partly relate to the relatively increased vascularity of the ovaries.
Microscopically, Krukenberg tumors are often characterized by mucin-secreting signet-ring cells in the tissue of the ovary; when the primary tumor is discovered, the same signet-ring cells are typically found. However, other microscopic features can predominate. Krukenberg tumors are most commonly metastases from gastric cancer, particularly adenocarcinoma, or breast cancer particularly invasive lobular breast carcinoma, but they can arise in the appendix, colon, small intestine, rectum, gallbladder, and urinary bladder or gallbladder, biliary tract, pancreas, ampulla of Vater or uterine cervix.
Immunohistochemistry may help in diagnosing Krukenberg tumors from primary ovarian neoplasms but needs to be applied with discretion. For example, tumors that are immunoreactive to CEA or cytokeratin 20 (CK20) and negative for cytokeratin 7 (CK7) may be more likely to be of colorectal origin.
In terms of the diagnosis of krukenburg tumors the following is done:
- CT scan
- CA-125 Test (elevated)
Since Krukenberg tumors are secondary (metastatic), management might logically be driven by identifying and treating the primary cancer. The optimal treatment of Krukenberg tumors is unclear. The role of surgical resection has not been adequately addressed but if metastasis is limited to the ovaries, surgery may improve survival. The role of chemotherapy and/or radiotherapy is uncertain but may sometimes be beneficial.
Krukenberg tumors account for about 15% of metastatic cancers that initially appear to have arisen in the ovary, and as such is less common than metastasis arising from ovarian epithelial and germ-cell tumors.
In people who have had nongynecologic malignancy, approximately 20% of adnexal masses are malignant, and 60% of these are Krukenberg tumors.
Krukenberg tumors are named after Friedrich Ernst Krukenberg (1871–1946), who reported what he thought was a new type of primary ovarian malignancy in 1896; six years later these were shown to be of metastatic gastrointestinal tract origin. However, Paget had described the process in 1854.
- ↑ 1.0 1.1 Ackerman LV, Rosai J (2004). Rosai and Ackerman's surgical pathology. Vol. 2. St. Louis: Mosby. p. 1708. ISBN 0-323-01342-2.
- ↑ 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 2.11 2.12 2.13 Al-Agha OM, Nicastri AD (November 2006). "An in-depth look at Krukenberg tumor: an overview". Archives of Pathology & Laboratory Medicine. 130 (11): 1725–1730. doi:10.5858/2006-130-1725-AILAKT. PMID 17076540.
- ↑ 3.0 3.1 3.2 Kiyokawa T, Young RH, Scully RE (March 2006). "Krukenberg tumors of the ovary: a clinicopathologic analysis of 120 cases with emphasis on their variable pathologic manifestations". The American Journal of Surgical Pathology. 30 (3): 277–299. doi:10.1097/01.pas.0000190787.85024.cb. PMID 16538048. S2CID 10359707.
- ↑ Papakonstantinou E, Liapis A, Kairi-Vassilatou E, Iavazzo C, Kleanthis CK, Kondi-Pafiti A (2011). "Virilizing ovarian Krukenberg tumor in a 27-year-old pregnant woman. A case report and literature review". European Journal of Gynaecological Oncology. 32 (3): 331–333. PMID 21797128.
- ↑ Todorov A, Sirakov N, Angelova I, Chervenkov L, Sirakov V, Georiev A, Stoeva M (2016). "The Leading Role of Computer Tomography for the Diagnose of Krukenberg Tumor With a Typical Symptomatology". Medical Physics International Journal. 4 (1): 59–60. ISSN 2306-4609.
- ↑ 6.0 6.1 6.2 6.3 6.4 6.5 Young RH (September 2006). "From krukenberg to today: the ever present problems posed by metastatic tumors in the ovary: part I. Historical perspective, general principles, mucinous tumors including the krukenberg tumor". Advances in Anatomic Pathology. 13 (5): 205–227. doi:10.1097/01.pap.0000213038.85704.e4. PMID 16998315. S2CID 9598841.
- ↑ Young RH (May 2007). "From Krukenberg to today: the ever present problems posed by metastatic tumors in the ovary. Part II". Advances in Anatomic Pathology. 14 (3): 149–177. doi:10.1097/PAP.0b013e3180504abf. PMID 17452813. S2CID 5609922.
- ↑ Aziz, Muhammad; Killeen, Robert B.; Kasi, Anup (2022). "Krukenberg Tumor". StatPearls. StatPearls Publishing. Archived from the original on 19 July 2022. Retrieved 1 December 2022.
- ↑ Cheong JH, Hyung WJ, Chen J, Kim J, Choi SH, Noh SH (August 2004). "Survival benefit of metastasectomy for Krukenberg tumors from gastric cancer". Gynecologic Oncology. 94 (2): 477–482. doi:10.1016/j.ygyno.2004.05.007. PMID 15297191.
- ↑ 10.0 10.1 Kim WY, Kim TJ, Kim SE, Lee JW, Lee JH, Kim BG, Bae DS (March 2010). "The role of cytoreductive surgery for non-genital tract metastatic tumors to the ovaries". European Journal of Obstetrics, Gynecology, and Reproductive Biology. 149 (1): 97–101. doi:10.1016/j.ejogrb.2009.11.011. PMID 20018420.
- ↑ Juretzka MM, Crawford CL, Lee C, Wilton A, Schuman S, Chi DS, et al. (May 2006). "Laparoscopic findings during adnexal surgery in women with a history of nongynecologic malignancy". Gynecologic Oncology. 101 (2): 327–330. doi:10.1016/j.ygyno.2005.10.025. PMID 16360202.
- ↑ Friedrich Ernst Krukenberg at Who Named It?