KCNK16

KCNK16
Identifiers
Aliases	KCNK16, K2p16.1, TALK-1, TALK1, potassium two pore domain channel subfamily K member 16
External IDs	OMIM: 607369 MGI: 1921821 HomoloGene: 75328 GeneCards: KCNK16
Gene location (Human) Chr. Chromosome 6 (human) Band 6p21.2 Start 39,314,698 bp End 39,322,968 bp
Gene location (Mouse) Chr. Chromosome 14 (mouse) Band 14 A3|14 Start 20,311,444 bp End 20,319,267 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in islet of Langerhans body of pancreas duodenum body of stomach fundus left lobe of thyroid gland ascending aorta right lung right lobe of thyroid gland intestinal epithelium Top expressed in islet of Langerhans yolk sac stomach lip hair follicle skin of abdomen skin of back duodenum submandibular gland liver More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding voltage-gated ion channel activity potassium channel activity potassium ion leak channel activity Cellular component integral component of membrane plasma membrane membrane integral component of plasma membrane Biological process potassium ion transport regulation of ion transmembrane transport ion transport potassium ion transmembrane transport stabilization of membrane potential Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 83795 74571 Ensembl ENSG00000095981 ENSMUSG00000023387 UniProt Q96T55 G5E845 RefSeq (mRNA) NM_001135105 NM_001135106 NM_001135107 NM_032115 NM_001363784 NM_029006 RefSeq (protein) NP_001128577 NP_001128578 NP_001128579 NP_115491 NP_001350713 NP_083282 Location (UCSC) Chr 6: 39.31 – 39.32 Mb Chr 14: 20.31 – 20.32 Mb PubMed search
Wikidata
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Potassium channel subfamily K member 16 is a protein that in humans is encoded by the KCNK16 gene. The protein encoded by this gene, K_2P16.1, is a potassium channel containing two pore-forming P domains.

See also

• Tandem pore domain potassium channel

Further reading

• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N (2001). "Potassium leak channels and the KCNK family of two-P-domain subunits". Nat. Rev. Neurosci. 2 (3): 175–84. doi:10.1038/35058574. PMID 11256078. S2CID 9682396.
• Han J, Kang D, Kim D (2003). "Functional properties of four splice variants of a human pancreatic tandem-pore K+ channel, TALK-1". Am. J. Physiol., Cell Physiol. 285 (3): C529–38. doi:10.1152/ajpcell.00601.2002. PMID 12724142. S2CID 23208697.
• Gierten J, Ficker E, Bloehs R, et al. (2008). "Regulation of two-pore-domain (K2P) potassium leak channels by the tyrosine kinase inhibitor genistein". Br. J. Pharmacol. 154 (8): 1680–90. doi:10.1038/bjp.2008.213. PMC 2518462. PMID 18516069.

External links

• KCNK16+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)