Protein-coding gene in the species Homo sapiens
Potassium channel, subfamily K, member 10 , also known as KCNK10 is a human gene . The protein encoded by this gene, K2P 10.1, is a potassium channel containing two pore-forming P domains.[5] [6] [7]
See also References
^ a b c GRCh38: Ensembl release 89: ENSG00000100433 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033854 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Lesage F, Terrenoire C, Romey G, Lazdunski M (September 2000). "Human TREK2, a 2P domain mechano-sensitive K+ channel with multiple regulations by polyunsaturated fatty acids, lysophospholipids, and Gs, Gi, and Gq protein-coupled receptors" . The Journal of Biological Chemistry . 275 (37): 28398–405. doi :10.1074/jbc.M002822200 PMID 10880510 . ^ Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (December 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels" . Pharmacological Reviews . 57 (4): 527–40. doi :10.1124/pr.57.4.12 . PMID 16382106 . S2CID 7356601 . ^ Dong YY, Pike AC, Mackenzie A, McClenaghan C, Aryal P, Dong L, Quigley A, Grieben M, Goubin S, Mukhopadhyay S, Ruda GF, Clausen MV, Cao L, Brennan PE, Burgess-Brown NA, Sansom MS, Tucker SJ, Carpenter EP (March 2015). "K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac" . Science . 347 (6227): 1256–9. Bibcode :2015Sci...347.1256D . doi :10.1126/science.1261512 . PMC 6034649 PMID 25766236 .
Further reading
Gu W, Schlichthörl G, Hirsch JR, Engels H, Karschin C, Karschin A, Derst C, Steinlein OK, Daut J (March 2002). "Expression pattern and functional characteristics of two novel splice variants of the two-pore-domain potassium channel TREK-2" . The Journal of Physiology . 539 (Pt 3): 657–68. doi :10.1113/jphysiol.2001.013432 . PMC 2290188 PMID 11897838 . Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N (March 2001). "Potassium leak channels and the KCNK family of two-P-domain subunits" . Nature Reviews. Neuroscience . 2 (3): 175–84. doi :10.1038/35058574 . PMID 11256078 . S2CID 9682396 . Gierten J, Ficker E, Bloehs R, Schlömer K, Kathöfer S, Scholz E, Zitron E, Kiesecker C, Bauer A, Becker R, Katus HA, Karle CA, Thomas D (August 2008). "Regulation of two-pore-domain (K2P) potassium leak channels by the tyrosine kinase inhibitor genistein" . British Journal of Pharmacology . 154 (8): 1680–90. doi :10.1038/bjp.2008.213 . PMC 2518462 PMID 18516069 . Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (April 1997). "Large-scale concatenation cDNA sequencing" . Genome Research . 7 (4): 353–8. doi :10.1101/gr.7.4.353 . PMC 139146 PMID 9110174 . Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (April 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry . 236 (1): 107–13. doi :10.1006/abio.1996.0138 . PMID 8619474 . Bang H, Kim Y, Kim D (June 2000). "TREK-2, a new member of the mechanosensitive tandem-pore K+ channel family" . The Journal of Biological Chemistry . 275 (23): 17412–9. doi :10.1074/jbc.M000445200 PMID 10747911 .
External links
