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Combination of
IsoniazidAnti-tuberculosis medication
Clinical data
Routes of
By mouth[1]
Defined daily dosenot established[2]

Isoniazid/pyridoxine/sulfamethoxazole/trimethoprim (INH/B6/CTX) is a fixed dose combination medication for the prevention of opportunistic infections in HIV/AIDS.[1] It combines isoniazid, pyridoxine, sulfamethoxazole, and trimethoprim.[1] Specifically it is used to prevent tuberculosis, toxoplasmosis, pneumonia, malaria, and isosporiasis.[3] It is taken by mouth.[1]

Side effects may include trouble concentrating, numbness, vomiting, and rash.[3] Serious side effects may include liver problems.[3] Caution may be required in people with G6PD deficiency.[3] While it has not been well studied, use in pregnancy appears to be okay.[3]

It is on the World Health Organization's List of Essential Medicines.[1] A year of medication is estimated to cost about US$15 in the developing world as of 2016.[3] While benefits include being able to take less pills, it is unclear if this version changes peoples adherence to treatment.[3] Other studies, however, have found fixed dose combinations to be useful for this purpose.[3]


The defined daily dose is not established.[2]


  1. 1.0 1.1 1.2 1.3 1.4 World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
  2. 2.0 2.1 "WHOCC - ATC/DDD Index". Archived from the original on 1 July 2021. Retrieved 11 September 2020.
  3. 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 "Isoniazid + pyridoxine + sulfamethoxazole + trimethoprim (New formulation) -- Adults". World Health Organization (WHO). Archived from the original on 3 February 2020. Retrieved 13 December 2017.

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