Intraneural perineurioma

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Intraneural perineurioma
Intraneural perineurioma image - enlarged and fibrotic lower trunk of brachial plexus arrowheads and normal divisions of upper trunk arrow ( clavicle asterisk)
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An intraneural perineurioma is a rare benign tumor within the sheath of a single nerve that grows but typically does not recur or metastasize. These lesions are only composed of perineurial cells, cloned from a single cell. They are distinct from schwannoma and neurofibroma.

"Intraneural perineurioma is a neoplastic proliferation of perineurial cells with unique immunohistochemistry and ultrastructural features, and it is distinct from other onion bulb Schwann cell-derived entities. Despite harboring molecular abnormalities of the long arm of chromosome 22, intraneural perineurioma has not been associated with neurofibromatosis."[1]


  1. Boyanton BL Jr; Jones JK; Shenaq SM; Hicks MJ; Bhattacharjee MB (2007). "Intraneural perineurioma: a systematic review with illustrative cases". Archives of Pathology & Laboratory Medicine. 131 (9): 1382–92. doi:10.1043/1543-2165(2007)131[1382:IPASRW]2.0.CO;2. PMID 17824794.

Further reading