Insulin glulisine

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Insulin glulisine
Insulin glulisine 6GV0 cartoon.png
PDB: 6gv0
Names
Trade namesApidra, Apidra SoloStar
Clinical data
Drug classInsulin (rapid acting)[1]
Main usesType 1 and type 2 diabetes[1]
Side effectsLow blood sugar, pain at the site of injection[2][1]
Pregnancy
category
  • AU: B3[3]
  • US: C (Risk not ruled out)[3]
Routes of
use
Subcutaneous, intravenous
External links
AHFS/Drugs.comMonograph
US NLMInsulin glulisine
MedlinePlusa607033
Legal
License data
Legal status
Chemical and physical data
FormulaC258H384N64O78S6
Molar mass5822.64 g·mol−1
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Insulin glulisine, sold under the brand name Apidra, is a rapid acting insulin used to treat type 1 and type 2 diabetes.[1] It is given by injection under the skin between 15 minutes before to 20 minutes after starting a meal.[1] It may also be used by injection into a vein.[4] It is generally used with a long acting insulin.[1]

Common side effects include low blood sugar and pain at the site of injection.[2][1] Other side effects may include allergic reactions, low potassium, and lipodystrophy.[1] It is made by recombinant DNA techniques.[2]

Insulin glulisine was approved for medical use in the United States and Europe in 2004.[1][2] In the United Kingdom 300 units costs the NHS about £6 as of 2021.[5] In the United States this amount costs just over 100 USD.[6]

Medical uses

Insulin glulisine is indicated for the treatment of diabetes mellitus.[2][4]

Dosage

The typical dose of all insulins in type 1 DM is 0.2 to 1 unit/kg per day.[1]

Chemistry

It differs from human insulin in that the amino acid asparagine at position B3 is replaced by lysine and the lysine in position B29 is replaced by glutamic acid.[7]

History

It was developed by Sanofi-Aventis.[8]

References

  1. 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 "Insulin Glulisine Monograph for Professionals". Drugs.com. Retrieved 26 November 2021.
  2. 2.0 2.1 2.2 2.3 2.4 2.5 "Apidra EPAR". European Medicines Agency (EMA). Retrieved 7 October 2020.
  3. 3.0 3.1 "Insulin glulisine Use During Pregnancy". Drugs.com. 6 April 2020. Retrieved 21 September 2020.
  4. 4.0 4.1 4.2 "Apidra- insulin glulisine injection, solution Apidra SoloStar- insulin glulisine injection, solution". DailyMed. 6 December 2019. Retrieved 21 September 2020.
  5. BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 754. ISBN 978-0857114105.
  6. "Apidra Prices, Coupons & Savings Tips". GoodRx. Retrieved 26 November 2021.
  7. "Apidra (insulin glulisine) injection, solution". DailyMed.
  8. Jasek W, ed. (2007). Austria-Codex (in Deutsch) (2007/2008 ed.). Vienna: Österreichischer Apothekerverlag. ISBN 978-3-85200-181-4.

External links

Identifiers: