|Hemosiderin staining around and above the ankle as an outcome of chronic hypertension|
It is caused by deposits of hemosiderin in skin. This may occur in purpura, haemochromatosis, hemorrhagic diseases, and stasis dermatitis. Localised hemosiderin hyperpigmentation may occur from a leaking venous catheter. One in five people receiving multiple blood transfusions can develop the condition. Diagnosis is by its appearance and sometimes requiring skin biopsy.
- James, William D.; Elston, Dirk; Treat, James R.; Rosenbach, Misha A.; Neuhaus, Isaac (2020). "36. Disturbances of pigmentation". Andrews' Diseases of the Skin: Clinical Dermatology (13th ed.). Edinburgh: Elsevier. pp. 862–863. ISBN 978-0-323-54753-6. Archived from the original on 2023-03-30. Retrieved 2023-05-06.