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Other names: Blood sweat, haematidrosis, hematohidrosis, hemidrosis
Red-tinted sweat (or "blood sweat") caused by hematohidrosis

Hematidrosis, also called blood sweat, is a very rare condition in which a human sweats blood.[1] The term is from Ancient Greek haîma/haímatos (αἷμα/αἵματος), meaning blood, and hīdrṓs (ἱδρώς), meaning sweat.

Signs and symptoms

At time of bleeding

Blood usually oozes from the forehead, nails, umbilicus, and other skin surfaces. In addition, oozing from mucocutaneous surfaces causing nosebleeds, bloodstained tears, and vicarious menstruation are common.[2] The episodes may be preceded by intense headache and abdominal pain and are usually self-limiting. In some conditions, the secreted fluid is more dilute and appears to be blood-tinged, while others may have darker bright red secretions resembling blood.[3]

While the extent of blood loss generally is minimal, hematidrosis also results in the skin becoming extremely tender and fragile.


Hematidrosis is a condition in which capillary blood vessels that feed the sweat glands rupture, causing them to exude blood, occurring under conditions of extreme physical or emotional stress.[4] Severe mental anxiety activates the sympathetic nervous system to invoke the stress- Fight-or-flight response to such a degree as to cause hemorrhage of the vessels supplying the sweat glands.[5] It has been suggested that acute fear and extreme stress can cause hematidrosis.[6]


Investigation such as platelets count, platelet aggregation test, coagulation profile and skin biopsy reveal no abnormalities and direct light microscopy of fluid demonstrates presence of normal red blood cells. Investigations also failed to show any vasculitis or skin appendages (i.e. sweat glands, sebaceous glands and hair follicles) abnormalities.[3][7]

A 2015 case study investigated hematidrosis with a patient who has epilepsy.[8]


Effect on the body is weakness and mild to moderate dehydration from the severe anxiety and both blood and sweat loss.[9]

The condition is very rare but there are reports in medical literature of successful treatment with beta blockers (propranolol 10 mg)[10][11] with significant reduction in the frequency of spontaneous blood oozing. The successful use of beta blockers supports the theory that the condition is induced by stress and anxiety yet this etiology is not established yet as the high prevalence of stress and anxiety in the modern era did not change the incidence of this extremely rare disease, suggesting that other co-abnormality also play a key role in this disease.[7] Atropine sulfate transdermal patches have also been used successfully.[3]

Favorable results with psychiatric counselling to reduce stress highlight the relationship between psychogenic causes and hematohidrosis.[5]

Jesus on the Mount of Olives


Dermatological research notes the presence of hematidrosis in people awaiting execution.[5] It has also been proposed as a possible explanation for Jesus' agony in the garden of Gethsemane (Luke 22:44)[12] and for claims associated with stigmata.[13][14]

Leonardo da Vinci described a soldier who sweated blood before battle. The phenomenon has also been observed in individuals in fear for their lives; a case occurred during the London blitz, and a case of fear of a storm while sailing, etc.[13]

See also


  1. Tshifularo, M. (2014). "Blood otorrhea: blood stained sweaty ear discharges: hematohidrosis; four case series (2001-2013)" (PDF). American Journal of Otolaryngology. 35 (2): 271–3. doi:10.1016/j.amjoto.2013.09.006. hdl:2263/42202. PMID 24315735. Archived from the original on 2022-04-30. Retrieved 2022-02-20.
  2. Holoubek, J. E.; Holoubek, A. B. (1996). "Blood, sweat and fear. "A classification of hematidrosis"". Journal of Medicine. 27 (3–4): 115–33. PMID 8982961.
  3. 3.0 3.1 3.2 Biswas, S.; Surana, T.; De, A.; Nag, F. (2013). "A curious case of sweating blood". Indian Journal of Dermatology. 58 (6): 478–80. doi:10.4103/0019-5154.119964. PMC 3827523. PMID 24249903.
  4. Freddrick Z., Dr "Hematidrosis"
  5. 5.0 5.1 5.2 Jerajani, H. R.; Jaju, Bhagyashri; Phiske, M. M.; Lade, Nitin (2009). "Hematohidrosis – A rare clinical phenomenon". Indian Journal of Dermatology. 54 (3): 290–2. doi:10.4103/0019-5154.55645. PMC 2810702. PMID 20161867.
  6. Holoubek JE; Holoubek AB (1996). "Blood, Sweat and Fear: A Classification of Hematidrosis". Journal of Medicine. 27 (3–4): 115–133. PMID 8982961.
  7. 7.0 7.1 Mora, E; Lucas, J (2013). "Hematidrosis: Blood sweat". Blood. 121 (9): 1493. doi:10.1182/blood-2012-09-450031. PMID 23570065.
  8. Shen H., Wang Z., Wu T., Wang J., Ren C., Chen H., Yu Z., Don W. (2015). "Haematidrosis associated with epilepsy in a girl successfully Treated with oxcarbazepine: Case report". Journal of International Medical. 43 (2): 263–69. doi:10.1177/0300060514562488. PMID 25673645.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  9. Zhang FK, Zheng YL, Liu JH, Chen HS, Liu SH, Xu MQ; et al. (2004). "Clinical and laboratory study of a case of hematidrosis". Zhonghua Xue Ye Xue Za Zhi. 25 (3): 147–50. PMID 15182582.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  10. Wang, Z.; Yu, Z.; Su, J.; Cao, L.; Zhao, X.; Bai, X.; Zhan, S.; Wu, T.; Jin, L.; Zhou, P.; Ruan, C. (2010). "A Case of Hematidrosis Successfully Treated with Propranolol". American Journal of Clinical Dermatology. 11 (6): 440–43. doi:10.2165/11531690-000000000-00000. PMID 20666570. S2CID 31593712.
  11. Khalid, S. R.; Maqbool, S; Raza, N; Mukhtar, T; Ikram, A; Qureshi, S (2013). "Ghost spell or hematohidrosis". Journal of the College of Physicians and Surgeons (JCPSP). 23 (4): 293–94. PMID 23552544.
  12. William D. Edwards; Wesley J. Gabel; Floyd E. Hosmer (March 21, 1986). "On the Physical Death of Jesus Christ" (PDF). JAMA. 255 (11): 1455–1463. CiteSeerX doi:10.1001/jama.1986.03370110077025. PMID 3512867. Archived (PDF) from the original on April 24, 2019. Retrieved February 20, 2022.{{cite journal}}: CS1 maint: uses authors parameter (link)
  13. 13.0 13.1 Manonukul J, Wisuthsarewong W, Chantorn R, Vongirad A, Omeapinyan P. (2008). Hematidrosis: A pathologic process or stigmata. A case report with comprehensive histopathologic and immunoperoxidase studies. Am J Dermatopathol 30: 135-139.
  14. Kluger, N; Cribier, B. (2013). Stigmata: From Saint-Francis of Assisi to Idiopathic Haematidrosis. Ann Dermatol Venereol 140: 771-777.