Heartland bandavirus

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Heartland bandavirus
Virus classification e
(unranked): Virus
Realm: Riboviria
Kingdom: Orthornavirae
Phylum: Negarnaviricota
Class: Ellioviricetes
Order: Bunyavirales
Family: Phenuiviridae
Genus: Bandavirus
Heartland bandavirus
  • Heartland virus
  • Heartland banyangvirus

Heartland bandavirus, sometimes called Heartland virus (HRTV), is a tick-borne phlebovirus of the Bhanja virus serocomplex discovered in 2009. The lone star tick transmits the virus to people when feeding on blood. As of 2017, only five states in the Central United States have reported 20 human infections, namely Arkansas, Indiana, Missouri, Oklahoma, and Tennessee; symptoms resemble those of two other tick-borne infections ehrlichiosis and anaplasmosis. The reservoir host is unknown, but deer, raccoon, coyotes, and moose in 13 different states have antibody titers against the virus. By 2023 over 50 human infections were reported in at least eleven states.[2][3]


The Heartland virus is part of the Bunyavirales order of viruses which contain 3 segments of −ssRNA. The genus of the virus is Phlebovirus and the species is the Heartland virus.[4]


Proposed transmission model for the Heartland virus[5]

In 2013, researchers from the CDC and Missouri Western State University first isolated the Heartland virus (HRTV) from the Lone Star Tick (Amblyomma americanum).[4][6] As of 2013 work continued to identify the reservoir host,[4] as HRTV has not been isolated from any wild or domestic animals though many white-tailed deer and raccoon from northwestern Missouri had antibodies to HRTV, suggesting that they may be hosts.

In a 2015 retrospective study using convenience samples of different wild animal sera deer, raccoon, coyotes, and moose had antibodies against HRTV. They lived in thirteen states: Florida, Georgia, Illinois, Indiana, Kansas, Kentucky, Missouri, North Carolina, Tennessee, Texas, but also New Hampshire, Maine and Vermont. The infections could have occurred as early as 2003, based on the estimated ages of affected deer. Since the Lone Star tick does not occur in northern New England it is assumed that a second type of tick can carry HRTV.[7]


a-d) Viral immunostaining of samples of heartland virus disease

Signs and symptoms

Signs and symptoms include fever in excess of 100.4 °F (38 °C), lethargy (weakness), headaches, muscle pain (myalgia), loss of appetite, nausea, diarrhea, weight loss, joint pain (arthralgia), low white blood cell count (leukopenia) and easy bruising due to a low platelet count (thrombocytopenia). Elevated liver transaminases may also be present.[8]

Risk factors

All known human cases have been reported from five U.S. states: Arkansas, Indiana, Missouri, Oklahoma, and Tennessee. Most people infected were spending time outdoors in regions where ticks are endemic. Most infections are diagnosed between May and September. People usually report having been bitten by a tick within two weeks prior to seeking health care.[citation needed]


Diagnosis is through the elimination of other causes of infectious diseases with related symptoms like ehrlichiosis and anaplasmosis or if the patient fails to respond to treatment with the antibiotic doxycycline. RT-PCR may then be used to detect viral ssRNA in the blood. Antibody titers against the virus may also be used to indicate infection with the Heartland virus.[9]


When planning to spend time outdoors in areas where the virus is known or suspected to be harbored by ticks, it is recommended that one cover the body completely with long sleeves and pants, and to avoid bushy and wooded areas. Although ticks are not consistently repelled by DEET-containing repellents, insect repellents should still be applied to one's body and gear. It is recommended that one perform thorough tick checks after being outside, and to remove any tick immediately. If a tick is found, one should remove the tick by the head, preferably with a pair of fine-tipped tweezers. Squeezing the abdomen of a tick while it is attached can force viruses and bacteria into the wound, increasing the chance of infection. Crushing an unattached tick will also release bacteria and viruses from its abdomen, which may then be able to enter a wound or burrow through the skin.[citation needed]


Treatment is non-specific. Antibiotics are not useful against viruses. Intravenous fluid administration and medications for the relief of pain are currently the best options.[10]


More than 20 human infections have been reported in the United States,[11] but given the obscurity of the disease, the true number of cases is suspected to be substantially larger.

Heartland virus cases
Year Location Deaths Cases
2009 Northwestern Missouri 0 2
2012–2013[9] Missouri, Tennessee[12] 1 6
2014 Missouri,[13] Oklahoma[14] 1 3
2017 Northwestern Arkansas,[11] Indiana [15] 0 3
2023 Maryland/Virginia[16] 1 1


The Heartland virus (HRTV) was discovered in 2009 in northwestern Missouri by Dr. Scott Folk of Heartland Regional Medical Center in St. Joseph, Missouri.[17] The virus was first proven to infect humans in June 2009 when two farmers, living 60 miles (97 km) apart, presented with fever, fatigue, diarrhea, thrombocytopenia, and leukopenia.[18] The Lone Star Tick transmits the virus to people when feeding on blood.


  1. Maes, Piet; Kuhn, Jens H. (31 August 2018). "Expansion of the order Bunyavirales" (docx). International Committee on Taxonomy of Viruses (ICTV). Archived from the original on 21 April 2023. Retrieved 20 December 2019. Heartland banyangvirus: derived from Heartland virus (and genus Banyangvirus)
  2. Ed Cara (24 Feb 2023) U.S. Man's Death Suggests Deadly Tick Virus Is Spreading to New Regions Archived 19 March 2023 at the Wayback Machine
  3. Sichen Liu, et. al. (May 2023) Fatal Case of Heartland Virus Disease Acquired in the Mid-Atlantic Region, United States Archived 2023-04-06 at the Wayback Machine
  4. 4.0 4.1 4.2 Schnirring, Lisa (2013-07-22). "Researchers trace novel Heartland virus to Missouri ticks". CIDRAP. Archived from the original on 2013-07-25. Retrieved 2013-07-23.
  5. Brault, Aaron C.; Savage, Harry M.; Duggal, Nisha K.; Eisen, Rebecca J.; Staples, J. Erin (14 September 2018). "Heartland Virus Epidemiology, Vector Association, and Disease Potential". Viruses. 10 (9): 498. doi:10.3390/v10090498. ISSN 1999-4915. Retrieved 21 April 2023.review
  6. Harry M. Savage; Marvin S. Godsey Jr.; Amy Lambert; Nickolas A. Panella; Kristen L. Burkhalter; Jessica R. Harmon; R. Ryan Lash; David C. Ashley; William L. Nicholson (22 July 2013). "First Detection of Heartland Virus (Bunyaviridae: Phlebovirus) from Field Collected Arthropods". Am J Trop Med Hyg. 89 (3): 445–452. doi:10.4269/ajtmh.13-0209. PMC 3771279. PMID 23878186.
  7. Riemersma KK, Komar N. Heartland Virus Neutralizing Antibodies in Vertebrate Wildlife, United States, 2009–2014. Archived 2023-03-18 at the Wayback Machine Emerg Infect Dis. 2015 Oct;21(10):1830–3. doi:10.3201/eid2110.150380
  8. Laura K. McMullan; Scott M. Folk; Aubree J. Kelly; Adam MacNeil; Cynthia S. Goldsmith; Maureen G. Metcalfe; Brigid C. Batten; César G. Albariño; Sherif R. Zaki; Pierre E. Rollin; William L. Nicholson; Stuart T. Nichol (2012-08-30). "A New Phlebovirus Associated with Severe Febrile Illness in Missouri". New England Journal of Medicine. 367 (9): 834–841. doi:10.1056/NEJMoa1203378. PMID 22931317.
  9. 9.0 9.1 Pastula, DM; Turabelidze, G; Yates, KF; Jones, TF; Lambert, AJ; Panella, AJ; Kosoy, OI; Velez, JO; Fisher, M; Staples, E (Mar 2014). "Notes from the field: Heartland virus disease - United States, 2012–2013". MMWR Morb Mortal Wkly Rep. 63 (12): 270–1. PMC 5779346. PMID 24670929. Archived from the original on 2022-03-21. Retrieved 2023-04-08.
  10. CDC Media relations CDC Reports More Cases of Heartland Virus Disease Archived 2023-04-12 at the Wayback Machine CDC press release, 27 March 2014
  11. 11.0 11.1 "Case of Heartland virus found in Arkansas resident". Arkansas Department of Health. July 7, 2017. Archived from the original on June 2, 2019. Retrieved July 7, 2017.
  12. Muehlenbachs A, Fata CR, Lambert AJ, Paddock CD, Velez JO, Blau DM, Staples JE, Karlekar MB, Bhatnagar J, Nasci RS, Zaki SR.Heartland Virus–Associated Death in Tennessee Clin Infect Dis. 2014 Sep 15;59(6):845–50. doi:10.1093/cid/ciu434
  13. TEDDYE SNELL Taking up arms against Heartland disease Archived 2014-07-28 at the Wayback Machine, Tahlequah Daily Press, June 18, 2014
  14. Associated Press Rare Heartland virus kills man in Oklahoma Archived 2021-03-01 at the Wayback Machine CBS News, May 28, 2014
  15. Indiana State Department of Health two cases of Heartland virus confirmed in Indiana Archived 2018-04-12 at the Wayback Machine, 7/11/2017
  16. Liu, Sichen; Kannan, Suraj; Meeks, Monica; Sanchez, Sandra; Girone, Kyle W.; Broyhill, James C.; Martines, Roosecelis Brasil; Bernick, Joshua; Flammia, Lori; Murphy, Julia; Hills, Susan L.; Burkhalter, Kristen L.; Laven, Janeen J.; Gaines, David; Hoffmann, Christopher J. "Early Release - Fatal Case of Heartland Virus Disease Acquired in the Mid-Atlantic Region, United States - Volume 29, Number 5—May 2023 - Emerging Infectious Diseases journal - CDC". doi:10.3201/eid2905.221488. Archived from the original on 2023-04-06. Retrieved 2023-04-08. {{cite journal}}: Cite journal requires |journal= (help)
  17. Knox, Richard (29 August 2012). "Mysterious New 'Heartland Virus' Discovered in Missouri". Shots: NPR's Health Blog. NPR. Archived from the original on 2012-08-30. Retrieved 2012-08-30.
  18. Grady, Denise (2012-09-03). "New Virus Tied to Ticks Poses Puzzle for Doctors". New York Times. Archived from the original on 2012-09-07. Retrieved 2012-09-07.