Hemochromatosis type 4

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Haemochromatosis type 4
Other names: Ferroportin disease
SpecialtyHepatology, Medical genetics
CausesMutation in ferroportin gene
Differential diagnosisHereditary hemochromatosis
TreatmentPhlebotomy, Iron chelation
FrequencyRare

Hemochromatosis type 4 is a hereditary iron overload disorder that affects ferroportin, an iron transport protein needed to export iron from cells into circulation.[1] Although the disease is rare, it is found throughout the world and affects people from various ethnic groups. While the majority of individuals with type 4 hemochromatosis have a relatively mild form of the disease, some affected individuals have a more severe form. As the disease progresses, iron may accumulate in the tissues of affected individuals over time, potentially resulting in organ damage.[2]

Signs and symptoms

Symptoms vary greatly between individuals with type 4 hemochromatosis. This difference in symptoms is likely due to the different types of SLC40A1 mutations patients may have.[3] In general, signs and symptoms of type 4 hemochromatosis are caused by excess iron in cells, which leads to tissue damage. The damage is largely due to iron-catalyzed oxidative reactions. Iron can exchange electrons with a variety of substrates, which can lead to generation of reactive oxygen species. This can lead to oxidative stress, lipid peroxidation, and DNA damage, which may result in cell death.[4] Two main forms of hemochromatosis type 4 exist (A and B), and the symptoms of these forms are distinct from one another.[5]

Type 4A hemochromatosis typically has milder symptoms than other types of hemochromatosis. Individuals with type 4A hemochromatosis tend to have hyperferritinemia (elevated ferritin in the blood plasma) and low saturated transferrin levels. These individuals are likely to have liver and spleen iron overload, primarily in Kupffer cells and other macrophages.[6] Because iron export is impaired, iron is unavailable for transport by circulating transferrin. This iron unavailability potentially leads to mild anemia in type 4A hemochromatosis patients because iron is necessary for hemoglobin synthesis, and red blood cells have a relatively high turnover rate.[7] Over time, iron stores increase, and individuals with type 4A hemochromatosis may develop hepatic fibrosis.[8]

The symptoms of type 4B hemochromatosis tend to be more severe. They resemble the symptoms of hemochromatosis types 1, 2, and 3. Plasma iron concentration is elevated, and symptoms include joint pain, diabetes, and arrhythmia. Liver iron deposition tends to be greater in type 4B than in type 4A.[9] Liver damage occurs more frequently in this form of hemochromatosis than in type 4A, and some individuals develop cirrhosis of the liver.[10]

Genetics

Type 4 hemochromatosis is caused by mutations of the SLC40A1 gene, located on the long arm of chromosome 2, specifically at 2q32.2. The SLC40A1 gene encodes ferroportin, a protein responsible for exporting iron from cells in the intestine, liver, spleen, and kidney, as well as from reticuloendothelial macrophages and the placenta.[11][12] More than 39 mutations to the SLC40A1 gene have been identified in patients with type 4 hemochromatosis.[13] All reported SLC40A1 mutations are deletions or missense mutations, which lead to amino acid substitution.[14]

Mutations to SLC40A1 that change the amino acid sequence can result in loss of function or gain of function for the resulting ferroportin protein. The loss of function mutation results in a phenotype that is different from that of a gain of function mutation, and these phenotypes are associated with two different forms of type 4 hemochromatosis. Loss-of-function mutations are more frequent and are associated with type 4A hemochromatosis. These mutations lead to a defect in the localization of ferroportin. Gain-of-function mutations are associated with type 4B and lead to production of ferroportin that resists negative regulation by hepcidin.[15][16]

Unlike other forms of hemochromatosis, which have a recessive pattern of inheritance, type 4 is an autosomal dominant disorder. The dominant inheritance pattern occurs in hemochromatosis type 4 because ferroportin is multimeric. Consequently, mutant ferroportin can associate with wild-type ferroportin in multimers and interfere with the function of normal ferroportin proteins.[17]

Pathophysiology

Microanalysis of hepatocytes in ferroportin disease-distribution of iron complex elements of oxygen (O K), phosphorus (P K), and iron (Fe K) and cuproprotein elements of sulfur (S K) and copper (Cu K)

In normal iron regulation, iron is absorbed in the intestine, and ferroportin transports iron from the cells of the intestinal lining into the bloodstream. Iron in the bloodstream is then bound by transferrin, which carries the iron to target cells. Iron is stored in cells and blood serum in a protein called ferritin. Reticuloendothelial macrophages, which can phagocytose red blood cells, are important in the iron recycling process. Ferroportin is upregulated in the reticuloendothelial macrophages after phagocytosis occurs so that iron from the degraded red blood cells can be released into the bloodstream and transported to other types of cells as needed. Hepcidin, a protein synthesized in the liver in response to iron or inflammation, is a regulator of ferroportin expression. When hepcidin binds ferroportin, ferroportin is phosphorylated, endocytosed, tagged with ubiquitin, and degraded.[18][19] More than 39 mutations to the SLC40A1 gene have been identified in patients with type 4 hemochromatosis.[20] The misregulation of ferroportin in type 4 hemochromatosis can involve a failure of ferroportin to be properly expressed at the cell membrane, or it can involve a failure of ferroportin to respond to negative regulation by hepcidin.[21]

Hemochromatosis type 4A is characterized by impaired iron export in cells. Reticuloendothelial macrophages are most affected. Iron accumulates preferentially in Kupffer cells, which are located in the liver, and serum ferritin increases; less iron is available for circulating transferrin, a protein that binds iron and transports it through the bloodstream to cell receptors.[22][23] This means that, while iron is trapped in certain types of tissues, it cannot be transported to tissues where it is needed. The accumulation of iron in tissues due to impaired iron export can lead to increasing transferrin iron saturation and liver parenchymal iron overload in advanced stages of the disease.[24] More ferritin is produced to suppress oxidative cell damage, although the amount of ferritin that cells can accumulate is limited.[25]

Hemochromatosis type 4B is characterized by abnormal iron release from macrophages and enterocytes because the mutant ferroportin is resistant to the hepcidin protein, which serves a regulatory function in wild-type ferroportin.[26] Intestinal iron absorption and release of iron from macrophages is increased.[27] Thus, this form of the disease leads to elevated transferrin saturation levels.[28] Systemic iron overload results, and liver iron deposition is primarily in the hepatocytes.[29]

Diagnosis

Diagnosis is based upon identification of symptoms, medical history, family history, and laboratory tests. Blood tests may show high levels of ferritin and low, normal, or high levels of transferrin saturation, depending on the form of hemochromatosis. The diagnosis must be confirmed by genetic testing for SLC40A1 mutations.[30]

Treatment

Treatment is based on the symptoms and severity of the disease. Iron chelators may be used to bind excess iron in tissues and allow for excretion of the excess metal.[31] Individuals with hemochromatosis type 4B may be treated with therapeutic phlebotomy. However, individuals with hemochromatosis type 4A may not require treatment. Additionally, therapeutic phlebotomy may not be tolerated in individuals with type 4A because anemia may develop despite the elevated serum ferritin levels typically found in these individuals.[32]

Epidemiology

Ferroportin disease is rare.[33]

References

  1. ↑ Roetto, A.; Camaschella, C. (2005). "New insights into iron homeostasis through the study of non-HFE hereditary haemochromatosis". Best Practice & Research Clinical Haematology. 18 (2): 235–250. doi:10.1016/j.beha.2004.09.004. PMID 15737887.
  2. ↑ Pietrangelo, A. (2004). "Non-HFE hemochromatosis". Hepatology. 39 (1): 21–29. doi:10.1002/hep.20007. PMID 14752817.
  3. ↑ Wallace, D.F.; Subramaniam, V.N. (2007). "Non-HFE haemochromatosis". World Journal of Gastroenterology. 13 (35): 4690–4698. doi:10.3748/wjg.v13.i35.4690. PMC 4611190. PMID 17729390.
  4. ↑ Gozzelino, R.; Arosio, P. (2016). "Iron homeostasis in health and disease". International Journal of Molecular Sciences. 17 (1): 130. doi:10.3390/ijms17010130. PMC 4730371. PMID 26805813.
  5. ↑ Wallace, D.F.; Subramaniam, V.N. (2007). "Non-HFE haemochromatosis". World Journal of Gastroenterology. 13 (35): 4690–4698. doi:10.3748/wjg.v13.i35.4690. PMC 4611190. PMID 17729390.
  6. ↑ Porto, G.; Brissot, P.; Swinkels, D.W.; Zoller, H.; Kamarainen, O.; Patton, S.; Alonso, I.; Morris, M.; Keeney, S. (2016). "EMQN best practice guidelines for the molecular genetic diagnosis of hereditary hemochromatosis (HH)". European Journal of Human Genetics. 24 (4): 479–495. doi:10.1038/ejhg.2015.128. PMC 4929861. PMID 26153218.
  7. ↑ Gozzelino, R.; Arosio, P. (2016). "Iron homeostasis in health and disease". International Journal of Molecular Sciences. 17 (1): 130. doi:10.3390/ijms17010130. PMC 4730371. PMID 26805813.
  8. ↑ Wallace, D.F.; Subramaniam, V.N. (2007). "Non-HFE haemochromatosis". World Journal of Gastroenterology. 13 (35): 4690–4698. doi:10.3748/wjg.v13.i35.4690. PMC 4611190. PMID 17729390.
  9. ↑ Porto, G.; Brissot, P.; Swinkels, D.W.; Zoller, H.; Kamarainen, O.; Patton, S.; Alonso, I.; Morris, M.; Keeney, S. (2016). "EMQN best practice guidelines for the molecular genetic diagnosis of hereditary hemochromatosis (HH)". European Journal of Human Genetics. 24 (4): 479–495. doi:10.1038/ejhg.2015.128. PMC 4929861. PMID 26153218.
  10. ↑ Wallace, D.F.; Subramaniam, V.N. (2007). "Non-HFE haemochromatosis". World Journal of Gastroenterology. 13 (35): 4690–4698. doi:10.3748/wjg.v13.i35.4690. PMC 4611190. PMID 17729390.
  11. ↑ MacKenzie, E.L.; Iwasaki, K.; Tsuji, Y. (2008). "Intracellular iron transport and storage: from molecular mechanisms to health implications". Antioxid. Redox Signal. 10 (6): 997–1030. doi:10.1089/ars.2007.1893. PMC 2932529. PMID 18327971.
  12. ↑ Chen, S.R.; Yang, L.Q.; Chong, Y.T.; Jie, Y.S.; Wu, Y.K.; Yang, J.; Lin, G.L.; Li, X.H. (2015). "Novel gain of function mutation in the SLC40A1 gene associated with hereditary haemochromatosis type 4". Internal Medicine Journal. 45 (6): 672–676. doi:10.1111/imj.12764. PMID 26059880. S2CID 2426509.
  13. ↑ Chen, S.R.; Yang, L.Q.; Chong, Y.T.; Jie, Y.S.; Wu, Y.K.; Yang, J.; Lin, G.L.; Li, X.H. (2015). "Novel gain of function mutation in the SLC40A1 gene associated with hereditary haemochromatosis type 4". Internal Medicine Journal. 45 (6): 672–676. doi:10.1111/imj.12764. PMID 26059880. S2CID 2426509.
  14. ↑ Domenico, I.; Ward, D.M.; Nemeth, E.; Vaughan, M.B.; Musci, G.; Ganz, T.; Kaplan, J.; Kornfeld, S.A. (2005). "The molecular basis of ferroportin-linked hemochromatosis". Proceedings of the National Academy of Sciences of the United States of America. 102 (25): 8955–8960. Bibcode:2005PNAS..102.8955D. doi:10.1073/pnas.0503804102. PMC 1157058. PMID 15956209.
  15. ↑ Domenico, I.; Ward, D.M.; Nemeth, E.; Vaughan, M.B.; Musci, G.; Ganz, T.; Kaplan, J.; Kornfeld, S.A. (2005). "The molecular basis of ferroportin-linked hemochromatosis". Proceedings of the National Academy of Sciences of the United States of America. 102 (25): 8955–8960. Bibcode:2005PNAS..102.8955D. doi:10.1073/pnas.0503804102. PMC 1157058. PMID 15956209.
  16. ↑ Callebaut, I.; Joubrel, R.; Pissard, S.; Kannengiesser, C.; Gerolami, V.; Ged, C.; Cadet, E.; Cartault, F.; Ka, C.; Gourlaouen, I.; Gourhant, L.; Oudin, C.; Goossens, M.; Grandchamp, B.; De Verneuil, H.; Rochette, J.; Ferec, C.; LeGac, G. (2014). "Comprehensive functional annotationof 18 missense mutations found in suspected hemochromatosis type 4 patients". Human Molecular Genetics. 23 (17): 4479–4490. doi:10.1093/hmg/ddu160. PMID 24714983.
  17. ↑ Domenico, I.; Ward, D.M.; Nemeth, E.; Vaughan, M.B.; Musci, G.; Ganz, T.; Kaplan, J.; Kornfeld, S.A. (2005). "The molecular basis of ferroportin-linked hemochromatosis". Proceedings of the National Academy of Sciences of the United States of America. 102 (25): 8955–8960. Bibcode:2005PNAS..102.8955D. doi:10.1073/pnas.0503804102. PMC 1157058. PMID 15956209.
  18. ↑ MacKenzie, E.L.; Iwasaki, K.; Tsuji, Y. (2008). "Intracellular iron transport and storage: from molecular mechanisms to health implications". Antioxid. Redox Signal. 10 (6): 997–1030. doi:10.1089/ars.2007.1893. PMC 2932529. PMID 18327971.
  19. ↑ Chen, S.R.; Yang, L.Q.; Chong, Y.T.; Jie, Y.S.; Wu, Y.K.; Yang, J.; Lin, G.L.; Li, X.H. (2015). "Novel gain of function mutation in the SLC40A1 gene associated with hereditary haemochromatosis type 4". Internal Medicine Journal. 45 (6): 672–676. doi:10.1111/imj.12764. PMID 26059880. S2CID 2426509.
  20. ↑ Chen, S.R.; Yang, L.Q.; Chong, Y.T.; Jie, Y.S.; Wu, Y.K.; Yang, J.; Lin, G.L.; Li, X.H. (2015). "Novel gain of function mutation in the SLC40A1 gene associated with hereditary haemochromatosis type 4". Internal Medicine Journal. 45 (6): 672–676. doi:10.1111/imj.12764. PMID 26059880. S2CID 2426509.
  21. ↑ Domenico, I.; Ward, D.M.; Nemeth, E.; Vaughan, M.B.; Musci, G.; Ganz, T.; Kaplan, J.; Kornfeld, S.A. (2005). "The molecular basis of ferroportin-linked hemochromatosis". Proceedings of the National Academy of Sciences of the United States of America. 102 (25): 8955–8960. Bibcode:2005PNAS..102.8955D. doi:10.1073/pnas.0503804102. PMC 1157058. PMID 15956209.
  22. ↑ Goodsell, D.S. (2002). "Ferritin and transferrin". RCSB Protein Data Bank. doi:10.2210/rcsb_pdb/mom_2002_11. Archived from the original on 6 December 2016. Retrieved 9 November 2016.
  23. ↑ Franchini, M. (2006). "Hereditary iron overload: update on pathophysiology, diagnosis, and treatment". Am. J. Hematol. 81 (3): 202–209. doi:10.1002/ajh.20493. PMID 16493621.
  24. ↑ Wallace, D.F.; Subramaniam, V.N. (2007). "Non-HFE haemochromatosis". World Journal of Gastroenterology. 13 (35): 4690–4698. doi:10.3748/wjg.v13.i35.4690. PMC 4611190. PMID 17729390.
  25. ↑ Eaton, J.W.; Qian, M. (2002). "Molecular bases of cellular iron toxicity". Free Radical Biology and Medicine. 32 (9): 833–840. doi:10.1016/s0891-5849(02)00772-4. PMID 11978485.
  26. ↑ Callebaut, I.; Joubrel, R.; Pissard, S.; Kannengiesser, C.; Gerolami, V.; Ged, C.; Cadet, E.; Cartault, F.; Ka, C.; Gourlaouen, I.; Gourhant, L.; Oudin, C.; Goossens, M.; Grandchamp, B.; De Verneuil, H.; Rochette, J.; Ferec, C.; LeGac, G. (2014). "Comprehensive functional annotationof 18 missense mutations found in suspected hemochromatosis type 4 patients". Human Molecular Genetics. 23 (17): 4479–4490. doi:10.1093/hmg/ddu160. PMID 24714983.
  27. ↑ Wallace, D.F.; Subramaniam, V.N. (2007). "Non-HFE haemochromatosis". World Journal of Gastroenterology. 13 (35): 4690–4698. doi:10.3748/wjg.v13.i35.4690. PMC 4611190. PMID 17729390.
  28. ↑ Callebaut, I.; Joubrel, R.; Pissard, S.; Kannengiesser, C.; Gerolami, V.; Ged, C.; Cadet, E.; Cartault, F.; Ka, C.; Gourlaouen, I.; Gourhant, L.; Oudin, C.; Goossens, M.; Grandchamp, B.; De Verneuil, H.; Rochette, J.; Ferec, C.; LeGac, G. (2014). "Comprehensive functional annotationof 18 missense mutations found in suspected hemochromatosis type 4 patients". Human Molecular Genetics. 23 (17): 4479–4490. doi:10.1093/hmg/ddu160. PMID 24714983.
  29. ↑ Kasvosve, I. (2013). "Effect of ferroportin polymorphism on iron homeostasis and infection". Clinica Chimica Acta. 416: 20–25. doi:10.1016/j.cca.2012.11.013. PMID 23178444.
  30. ↑ "Ferroportin Disease". National Organization for Rare Disorders. Archived from the original on 16 November 2016. Retrieved 9 November 2016.
  31. ↑ Santos, P.C.J.L.; Dinardo, C.L.; Cancado, R.D.; Schettert, I.T.; Krieger, J.E.; Periera, A.C. (2012). "Non-HFE hemochromatosis". Revista Brasileira de Hematologia e Hemoterapia. 34 (4): 311–6. doi:10.5581/1516-8484.20120079. PMC 3460409. PMID 23049448.
  32. ↑ Franchini, M. (2006). "Hereditary iron overload: update on pathophysiology, diagnosis, and treatment". Am. J. Hematol. 81 (3): 202–209. doi:10.1002/ajh.20493. PMID 16493621.
  33. ↑ Palmer, WC; Vishnu, P; Sanchez, W; Aqel, B; Riegert-Johnson, D; Seaman, LAK; Bowman, AW; Rivera, CE (December 2018). "Diagnosis and Management of Genetic Iron Overload Disorders". Journal of General Internal Medicine. 33 (12): 2230–2236. doi:10.1007/s11606-018-4669-2. PMC 6258594. PMID 30225768.

External links

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