HLA-Cw4

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HLA-Cw4
(MHC Class I, C cell surface antigen)
HLA-Cw4
About
Proteintransmembrane receptor/ligand
Structureαβ heterodimer
SubunitsHLA-Cw*04--, β2-microglobulin
Older names-
Subtypes
Subtype
allele
Available structures
Cw4 *0401
{{{cNick2}}} *04{{{cAllele2}}}
{{{cNick3}}} *04{{{cAllele3}}}
{{{cNick4}}} *04{{{cAllele4}}}
Rare alleles
Subtype
allele
Available structures
Cw403 *0403
{{{rnick2}}} *04{{{rallele2}}}
{{{rnick3}}} *04{{{rallele3}}}
Alleles link-out to IMGT/HLA database at EBI

HLA-Cw4 (Cw4) is a human leukocyte antigen serotype within HLA-C serotype group. (For more general information on HLA serotypes, please see the article: History and naming of human leukocyte antigens.) Cw4 is determined by the antibody recognition of α4 subset of HLA-Cw α-chains. For the serotype Cw4, the alpha chain are encoded by the HLA-Cw*04 allele group and the β-chain are encoded by B2M locus.[1] Cw4 and Cw*04 are almost synonymous in meaning. Cw4 is more common in Southeast Europe, where it is part of the Cw4-B35 haplotype.

Serotype

Cw4 recognition of some HLA Cw*04 gene products[2]
Cw*04 Cw4 Cw403 Cw6 Sample
allele % % % size (N)
*0401 98 0 0 736
*0403 37 5 17 25


Alleles

HLA Cw*0401 frequencies
Study populationFreq.
 (in %)[3]
Mexico Mixe Oaxaca37.8
Mexico Mixtec Oaxaca37.3
USA N. Mexico Canoncito N…31.7
Mexico Zaptotec Oaxaca30.6
Iran Baloch28.6
Australia Indig. Cape Yor…27.5
Australia Indig.Yuendumu26.8
Australia Indig. Groote E…25.3
Lebanon24.3
Israel Arab Druse22.5
Georgia Tbilisi Kurds22.4
Brazil Terena22.3
Georgia Tbilisi Georgian…22.0
India Tamil Nadu Nadar21.3
Mali Bandiagara21.3
Taiwan Ami20.9
Papua New Guinea Wanigela20.8
USA African Americans pop…19.6
Senegal Niokholo Mandenka19.5
Cameroon Beti18.7
Indig. Australian Kimberl…17.9
Papua New Guinea Wosera17.0
Italy North pop 116.7
New Caledonia16.7
Morocco Nador Metalsa (be…15.9
Portugal Centre pop 215.8
Cameroon Sawa15.4
India Mumbai Marathas15.4
Iran Tehran15.4
USA Hispanic15.0
PNG West Schrader Ranges14.8
Zimbabwe Harare Shona14.8
Swiss Geneva14.5
Zambia Lusaka14.4
Uganda Kampala14.1
Brazil13.7
Sudanese13.5
France West13.4
Tibetan13.3
Finland13.3
Kenya Luo13.2
Cameroon Bamileke13.0
Philippines Ivatan13.0
Kenya12.9
Singapore Riau Malay12.2
India North Delhi11.7
Tunisia11.6
Kenya Nandi11.5
Russia Tuva pop 211.5
Taiwan Bunun11.4
USA Caucasian pop211.1
India West Coast Parsis11.0
China Qinghai Hui10.9
Czech Republic10.8
India New Delhi10.7
Spain Eastern Andalusia10.4
UK Caucasians10.1
Cameroon Pygmy Baka10.0
China Beijing10.0
Jordan Amman10.0
Singapore Javanese10.0
Papua New Guinea Madang9.5
Saudi Arabia Guraiat and …9.5
Australia New South Wales9.4
USA Alaska Yupik Natives9.3
Bulgaria Gipsy9.1
Mex. Chihuahua Tarahumara9.1
German Essen9.0
France South East8.9
Taiwan Paiwan8.8
China Inner Mongolia8.3
Ireland Northern8.3
Venezuela Perija Yucpa8.3
South Korea (1)8.2
China North Han7.6
USA South Dakota Lakota S…7.4
Taiwan Atayal7.1
India West Bhils7.0
PNG Karimui Plateau6.9
Taiwan Siraya6.9
Taiwan Thao6.7
Japan (5)6.5
Thailand6.0
China Guangzhou5.6
USA Asian5.6
Ireland South5.4
PNG Eastern Highlands Gor…4.7
Japan Central4.6
Spain Eastern Andalusia G…4.5
China South Han4.4
South Africa Natal Tamil4.2
American Samoa4.0
Taiwan Saisiat3.9
Papua New Guinea New Brit…3.6
Taiwan Minnan pop 13.4
USA Hawaii Okinawa3.3
China Guangdong Meizhou H…3.0
India Khandesh Pawra3.0
Taiwan Puyuma3.0
Allele frequencies presented, only
HLA Cw*0403 frequencies
Study populationFreq.
 (in %)[3]
PNG West Schrader Ranges45.9
Taiwan Tao40.0
PMG Eastern Highlands Gor…34.9
PNG Madang25.0
PNG Wanigela16.0
Australia Indig. Cape Yor…15.7
Australia Indig. Yuendumu15.1
Australia Indig. Groote E…12.3
Taiwan Puyuma12.0
PNG Karimui Plateau11.9
Taiwan Pazeh11.8
Taiwan Thao11.7
New Caledonia11.1
Singapore Riau Malay9.8
PNG New Britain Rabaul8.9
PNG Wosera8.0
Singapore Javanese7.0
Taiwan Rukai7.0
Taiwan Bunun6.4
American Samoa6.0
Thailand5.3
Philippines Ivatan5.0
Taiwan Siraya4.9
Taiwan Tsou4.9
Australia Indig. Kimberly3.6
Taiwan Atayal3.3
South Africa Natal Tamil3.1
Taiwan Ami2.6
China South Han2.1
USA Asian2.0
Taiwan Hakka1.8
China Qinghai Hui1.4
Iran Tehran1.3
China Guangdong Meizhou H…1.0
China Inner Mongolia1.0
India West Coast Parsis1.0
Taiwan Minnan pop 11.0
Taiwan Paiwan1.0
India New Delhi0.9
Russia Tuva0.9
China Tibetan0.6
Allele frequencies presented, only

References

  1. ^ Arce-Gomez B, Jones EA, Barnstable CJ, Solomon E, Bodmer WF (February 1978). "The genetic control of HLA-A and B antigens in somatic cell hybrids: requirement for beta2 microglobulin". Tissue Antigens. 11 (2): 96–112. doi:10.1111/j.1399-0039.1978.tb01233.x. PMID 77067.
  2. ^ Allele Query Form IMGT/HLA - European Bioinformatics Institute
  3. ^ a b Middleton, D.; Menchaca, L.; Rood, H.; Komerofsky, R. (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens. 61 (5): 403–407. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660.
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