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Combination of
HydrochlorothiazideThiazide diuretic
TriamterenePotassium-sparing diuretic
Trade namesMaxzide, Dyazide, others
Clinical data
Routes of
By mouth
Defined daily dosenot established[1]
Legal status
  • In general: ℞ (Prescription only)

Hydrochlorothiazide/triamterene, also known as co-triamterzide, is a combination medication of hydrochlorothiazide and triamterene.[2] It is used to treat high blood pressure and swelling.[2] Specifically it is used in those who develop low blood potassium when on only hydrochlorothiazide.[3] It is taken by mouth.[2]

Side effects may include nausea, trouble sleeping, dizziness, feeling light headed with standing, kidney problems, allergies, and muscle cramps.[3] Other serious side effects may include high blood potassium.[3] Use in pregnancy and breastfeeding is not generally recommended.[3] Use in those with significant kidney problems is not recommended.[3] It decreases blood pressure mainly by hydrochlorothiazide while triamterene decreases the amount of potassium lost.[3]

The combination was approved for medical use in the United States in 1965.[3] A month supply in the United Kingdom costs the NHS about 0.95 £ per month as of 2019.[2] In the United States the wholesale cost of this amount is about 3.90 USD.[4] In 2017, it was the 101st most commonly prescribed medication in the United States, with more than seven million prescriptions.[5][6]


The defined daily dose is not established[1]


  1. 1.0 1.1 "WHOCC - ATC/DDD Index". www.whocc.no. Retrieved 10 September 2020.
  2. 2.0 2.1 2.2 2.3 British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 76. ISBN 9780857113382.
  3. 3.0 3.1 3.2 3.3 3.4 3.5 3.6 "Triamterene and Hydrochlorothiazide - FDA prescribing information, side effects and uses". Drugs.com. Retrieved 5 March 2019.
  4. "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services. Retrieved 3 March 2019.
  5. "The Top 300 of 2020". ClinCalc. Retrieved 11 April 2020.
  6. "Hydrochlorothiazide; Triamterene - Drug Usage Statistics". ClinCalc. Retrieved 11 April 2020.

External links