HBQ1

HBQ1
Identifiers
Aliases	HBQ1, HBQ, hemoglobin subunit theta 1
External IDs	OMIM: 142240 MGI: 3613460 HomoloGene: 3895 GeneCards: HBQ1
Gene location (Human) Chr. Chromosome 16 (human) Band 16p13.3 Start 180,459 bp End 181,179 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11|11 A4 Start 32,236,965 bp End 32,237,784 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in blood monocyte spongy bone nucleus accumbens bone marrow amygdala Brodmann area 9 caudate nucleus putamen hypothalamus Top expressed in bone marrow yolk sac spleen lobe of liver placenta superior frontal gyrus neural tube mesencephalon cerebellar cortex heart More reference expression data BioGPS More reference expression data
Gene ontology Molecular function iron ion binding oxygen binding protein binding heme binding metal ion binding oxygen carrier activity peroxidase activity haptoglobin binding organic acid binding Cellular component hemoglobin complex haptoglobin-hemoglobin complex Biological process oxygen transport hydrogen peroxide catabolic process protein heterooligomerization cellular oxidant detoxification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3049 544763 Ensembl ENSG00000086506 ENSMUSG00000073063 UniProt P09105 Q3U0A6 RefSeq (mRNA) NM_005331 NM_001033981 RefSeq (protein) NP_005322 NP_001029153 Location (UCSC) Chr 16: 0.18 – 0.18 Mb Chr 11: 32.24 – 32.24 Mb PubMed search
Wikidata
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Hemoglobin subunit theta-1 is a protein that in humans is encoded by the HBQ1 gene.

Theta-globin mRNA is found in human fetal erythroid tissue but not in adult erythroid or other nonerythroid tissue. The theta-1 gene may be expressed very early in embryonic life, perhaps sometime before 5 weeks. Theta-1 is a member of the human alpha-globin gene cluster that involves five functional genes and two pseudogenes. The order of genes is: 5' - zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta-1 - 3'. Research supports a transcriptionally active role for the gene and a functional role for the peptide in specific cells, possibly those of early erythroid tissue.

Further reading

• Giardina B, Messana I, Scatena R, Castagnola M (1995). "The multiple functions of hemoglobin". Crit. Rev. Biochem. Mol. Biol. 30 (3): 165–96. doi:10.3109/10409239509085142. PMID 7555018.
• Kim JH, Yu CY, Bailey A, et al. (1989). "Unique sequence organization and erythroid cell-specific nuclear factor-binding of mammalian theta 1 globin promoters". Nucleic Acids Res. 17 (14): 5687–700. doi:10.1093/nar/17.14.5687. PMC 318189. PMID 2569721.
• Ley TJ, Maloney KA, Gordon JI, Schwartz AL (1989). "Globin gene expression in erythroid human fetal liver cells". J. Clin. Invest. 83 (3): 1032–8. doi:10.1172/JCI113944. PMC 303780. PMID 2921315.
• Gonzalez-Redondo JM, Han IS, Gu YC, Huisman TH (1988). "Nucleotide sequence of the human theta 1-globin gene". Biochem. Genet. 26 (3–4): 207–11. doi:10.1007/BF00561460. PMID 3408475. S2CID 19352648.
• Hsu SL, Marks J, Shaw JP, et al. (1988). "Structure and expression of the human theta 1 globin gene". Nature. 331 (6151): 94–6. Bibcode:1988Natur.331...94H. doi:10.1038/331094a0. PMID 3422341. S2CID 4357357.
• Daniels RJ, Peden JF, Lloyd C, et al. (2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16". Hum. Mol. Genet. 10 (4): 339–52. doi:10.1093/hmg/10.4.339. PMID 11157797.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• De Gobbi M, Viprakasit V, Hughes JR, et al. (2006). "A regulatory SNP causes a human genetic disease by creating a new transcriptional promoter". Science. 312 (5777): 1215–7. Bibcode:2006Sci...312.1215D. doi:10.1126/science.1126431. PMID 16728641. S2CID 16044469.