Guillermina Lozano

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Guillermina Lozano
Alma materPan American University (BSc)
Rutgers University (PhD)
Scientific career
InstitutionsUniversity of Texas MD Anderson Cancer Center
ThesisIsolation, characterization and analysis of the gene encoding the Alpha 2 type IX collagen polypeptide (1986)

Guillermina 'Gigi' Lozano is an American geneticist. She is a professor at University of Texas MD Anderson Cancer Center. Lozano is recognised for her studies of the p53 tumour suppressor pathway, characterising the protein as a regulator of gene expression (transcription factor).

Early life and education

Lozano was born in East Chicago, Indiana, the daughter of Mexican immigrants. She attended a private Catholic high school, Bishop Noll, up until her senior year, when her family moved to McAllen, Texas.[1]

Lozano completed a Bachelor of Science in biology and mathematics, graduating Magna Cum Laude, at Pan American University (now University of Texas Rio Grande Valley) in 1979. She earned a doctor of philosophy in biochemistry from Rutgers University and University of Medicine and Dentistry of New Jersey in 1986.[2] Lozano's dissertation was titled Isolation, characterization and analysis of the gene encoding the Alpha 2 type IX collagen polypeptide.[3] She completed postgraduate training in molecular biology at Princeton University from 1985 to 1987.[2]

Career and research

Lozano is Professor and Chair of the Department of Genetics[4] at University of Texas MD Anderson Cancer Center. She is also a professor at University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences.[2]

Lozano is recognised for her studies of the p53[5] tumour suppressor pathway, from characterising p53 as a transcriptional activator[6] to revealing the importance of two inhibitors of p53, Mdm2 and Mdm4. Her lab has generated dozens of mouse models of p53 to explore effects of mutations in this tumor-suppressing protein on tumorogeneis.[7]

Awards and honours

Lozano is a member of the National Academy of Sciences,[8] National Academy of Medicine,[9] Academy of Medicine, Engineering and Science of Texas.[2]

Awards:

References

  1. ^ Hardy, Michael. "Her discovery expanded our knowledge of cancer genetics". MD Anderson Cancer Center. Retrieved 2023-02-21.
  2. ^ a b c d "Guillermina (Gigi) Lozano". MD Anderson Cancer Center. Retrieved 2018-12-10.
  3. ^ Lozano, Guillermina (1986). "Isolation, characterization and analysis of the gene encoding the Alpha 2 type IX collagen polypeptide". ProQuest Dissertations Publishing. Rutgers The State University of New Jersey. {{cite journal}}: Cite journal requires |journal= (help)
  4. ^ "Guillermina (Gigi) Lozano". MD Anderson Cancer Center. Retrieved 2022-02-11.
  5. ^ Moyer, Sydney M.; Wasylishen, Amanda R.; Qi, Yuan; Fowlkes, Natalie; Su, Xiaoping; Lozano, Guillermina (2020-09-22). "p53 drives a transcriptional program that elicits a non-cell-autonomous response and alters cell state in vivo". Proceedings of the National Academy of Sciences. 117 (38): 23663–23673. Bibcode:2020PNAS..11723663M. doi:10.1073/pnas.2008474117. ISSN 0027-8424. PMC 7519296. PMID 32900967.
  6. ^ "Transcriptional Activation by Wild-Type But Not Transforming Mutants of the p53 Anti-Oncogene", Science 31 August 1990
  7. ^ Jeffers, John R.; Pinto, Emilia M.; Rehg, Jerold E.; Clay, Michael R.; Wang, Jinling; Neale, Geoffrey; Heath, Richard J.; Lozano, Guillermina; Lalli, Enzo; Figueiredo, Bonald C.; Pappo, Alberto S. (2021-05-01). "The Common Germline TP53-R337H Mutation Is Hypomorphic and Confers Incomplete Penetrance and Late Tumor Onset in a Mouse Model". Cancer Research. 81 (9): 2442–2456. doi:10.1158/0008-5472.CAN-20-1750. ISSN 0008-5472. PMC 8137600. PMID 33637564.
  8. ^ a b "Guillermina Lozano". www.nasonline.org. Retrieved 2022-02-11.
  9. ^ "Member". National Academy of Medicine. Retrieved 2022-02-11.
  10. ^ "Guillermina (Gigi) Lozano, PhD". American Association for Cancer Research (AACR). Retrieved 2022-02-11.
  11. ^ "Guillermina Lozano". American Academy of Arts & Sciences. Retrieved 2022-02-11.
  12. ^ "E.E. Just Lecture", American Society for Cell Biology
  13. ^ "Guillermina Lozano Member Directory", National Academy of Sciences
  14. ^ "AACR-Women in Cancer Research Charlotte Friend Memorial Lectureship Recipients", American Association for Cancer Research
  15. ^ "AACR-Minorities in Cancer Research Jane Cooke Wright Memorial Lectureship Recipients", American Association for Cancer Research