GREB1

GREB1
Identifiers
Aliases	GREB1, growth regulation by estrogen in breast cancer 1, growth regulating estrogen receptor binding 1
External IDs	OMIM: 611736 MGI: 2149712 HomoloGene: 8780 GeneCards: GREB1
Gene location (Human) Chr. Chromosome 2 (human) Band 2p25.1 Start 11,482,341 bp End 11,642,788 bp
Gene location (Mouse) Chr. Chromosome 12 (mouse) Band 12|12 A1.1 Start 16,720,616 bp End 16,850,887 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in germinal epithelium canal of the cervix left uterine tube myometrium right uterine tube prostate endometrium vagina caput epididymis smooth muscle tissue Top expressed in cumulus cell primitive streak adrenal gland substantia nigra Paneth cell ovary trigeminal ganglion Bowman's capsule ciliary body yolk sac More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 9687 268527 Ensembl ENSG00000196208 ENSMUSG00000036523 UniProt Q4ZG55 Q3UHK3 RefSeq (mRNA) NM_014668 NM_033090 NM_148903 NM_001252071 NM_015764 RefSeq (protein) NP_055483 NP_149081 NP_683701 NP_001239000 NP_056579 Location (UCSC) Chr 2: 11.48 – 11.64 Mb Chr 12: 16.72 – 16.85 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Growth regulation by estrogen in breast cancer 1 is a protein that in humans is encoded by the GREB1 gene.

Function

This gene is an estrogen-responsive gene that is an early response gene in the estrogen receptor-regulated pathway. It is thought to play an important role in hormone-responsive tissues and cancer. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Further reading

• Hnatyszyn HJ, Liu M, Hilger A, Herbert L, Gomez-Fernandez CR, Jorda M, Thomas D, Rae JM, El-Ashry D, Lippman ME (2010). "Correlation of GREB1 mRNA with protein expression in breast cancer: Validation of a novel GREB1 monoclonal antibody". Breast Cancer Research and Treatment. 122 (2): 371–80. doi:10.1007/s10549-009-0584-x. PMID 19842031. S2CID 22189668.
• Deschênes J, Bourdeau V, White JH, Mader S (2007). "Regulation of GREB1 transcription by estrogen receptor alpha through a multipartite enhancer spread over 20 kb of upstream flanking sequences". Journal of Biological Chemistry. 282 (24): 17335–9. doi:10.1074/jbc.C700030200. PMID 17463000.
• Chand AL, Wijayakumara DD, Knower KC, Herridge KA, Howard TL, Lazarus KA, Clyne CD (2012). "The orphan nuclear receptor LRH-1 and ERα activate GREB1 expression to induce breast cancer cell proliferation". PLOS ONE. 7 (2): e31593. Bibcode:2012PLoSO...731593C. doi:10.1371/journal.pone.0031593. PMC 3281101. PMID 22359603.
• Pellegrini C, Gori I, Achtari C, Hornung D, Chardonnens E, Wunder D, Fiche M, Canny GO (2012). "The expression of estrogen receptors as well as GREB1, c-MYC, and cyclin D1, estrogen-regulated genes implicated in proliferation, is increased in peritoneal endometriosis". Fertility and Sterility. 98 (5): 1200–8. doi:10.1016/j.fertnstert.2012.06.056. PMID 22884659.
• Liu M, Wang G, Gomez-Fernandez CR, Guo S (2012). "GREB1 functions as a growth promoter and is modulated by IL6/STAT3 in breast cancer". PLOS ONE. 7 (10): e46410. Bibcode:2012PLoSO...746410L. doi:10.1371/journal.pone.0046410. PMC 3463574. PMID 23056300.
• Nyholt DR, Low SK, Anderson CA, Painter JN, Uno S, Morris AP, MacGregor S, Gordon SD, Henders AK, Martin NG, Attia J, Holliday EG, McEvoy M, Scott RJ, Kennedy SH, Treloar SA, Missmer SA, Adachi S, Tanaka K, Nakamura Y, Zondervan KT, Zembutsu H, Montgomery GW (2012). "Genome-wide association meta-analysis identifies new endometriosis risk loci" (PDF). Nature Genetics. 44 (12): 1355–9. doi:10.1038/ng.2445. PMC 3527416. PMID 23104006.
• Rae JM, Johnson MD, Cordero KE, Scheys JO, Larios JM, Gottardis MM, Pienta KJ, Lippman ME (2006). "GREB1 is a novel androgen-regulated gene required for prostate cancer growth". The Prostate. 66 (8): 886–94. doi:10.1002/pros.20403. hdl:2027.42/49275. PMID 16496412. S2CID 24744169.
• Rittié L, Kang S, Voorhees JJ, Fisher GJ (2008). "Induction of collagen by estradiol: Difference between sun-protected and photodamaged human skin in vivo". Archives of Dermatology. 144 (9): 1129–40. doi:10.1001/archderm.144.9.1129. PMID 18794456.
• Ghosh MG, Thompson DA, Weigel RJ (2000). "PDZK1 and GREB1 are estrogen-regulated genes expressed in hormone-responsive breast cancer". Cancer Research. 60 (22): 6367–75. PMID 11103799.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.